ArticlePloS one2014
A genome wide association study of mathematical ability reveals an association at chromosome 3q29, a locus associated with autism and learning difficulties: a preliminary study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability.Scientific reports · 2017Pooled it
- Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity.The European journal of neuroscience · 2026Review
- Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability.Molecular psychiatry · 2025Article
- The Geneticization of Education and Its Bioethical Implications.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2024Article
- A genome-wide association study identified new variants associated with mathematical abilities in Chinese children.Genes, brain, and behavior · 2023Article
- Associations Between Children's Numeracy Competencies, Mothers' and Fathers' Mathematical Beliefs, and Numeracy Activities at Home.Frontiers in psychology · 2022Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence.Scientific reports · 2021Article
- Neurobiological origins of individual differences in mathematical ability.PLoS biology · 2020Article
- Predictors of Children's Early Numeracy: Environmental Variables, Intergenerational Pathways, and Children's Cognitive, Linguistic, and Non-symbolic Number Skills.Frontiers in psychology · 2020Article
- Lack of replication for the myosin-18B association with mathematical ability in independent cohorts.Genes, brain, and behavior · 2015Article
- Developmental dyscalculia.European journal of pediatrics · 2015Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability. We carried out a genome wide association scan using pooled DNA in two groups of U.K. samples, based on end of secondary/high school national academic exam achievement: high (n = 419) versus low (n = 183) mathematical ability while controlling for their verbal ability. Significant differences in allele frequencies between these groups were searched for in 906,600 SNPs using the Affymetrix GeneChip Human Mapping version 6.0 array. After meeting a threshold of p<1.5×10(-5), 12 SNPs from the pooled association analysis were individually genotyped in 542 of the participants and analyzed to validate the initial associations (lowest p-value 1.14 ×10(-6)). In this analysis, one of the SNPs (rs789859) showed significant association after Bonferroni correction, and four (rs10873824, rs4144887, rs12130910 rs2809115) were nominally significant (lowest p-value 3.278 × 10(-4)). Three of the SNPs of interest are located within, or near to, known genes (FAM43A, SFT2D1, C14orf64). The SNP that showed the strongest association, rs789859, is located in a region on chromosome 3q29 that has been previously linked to learning difficulties and autism. rs789859 lies 1.3 kbp downstream of LSG1, and 700 bp upstream of FAM43A, mapping within the potential promoter/regulatory region of the latter. To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.