Evidence map›Paper›PMID 24801367›Full record

Trial reportEuropean journal of clinical nutrition2014

A candidate gene approach for identifying differential iron responses in young overweight women to an energy-restricted haem iron-rich diet.

H L Cheng, D P Hancock, K B Rooney, K S Steinbeck, H J Griffin, H T O'Connor

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Common Variants in theCurrent developments in nutrition · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

H L ChengDiscipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
D P HancockSchool of Molecular Bioscience, The University of Sydney, Lidcombe, NSW, Australia.
K B RooneyDiscipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
K S SteinbeckAcademic Department of Adolescent Medicine, The University of Sydney, Lidcombe, NSW, Australia.
H J GriffinDiscipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
H T O'ConnorDiscipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.
University of Sydney · AUBankstown Lidcombe Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although iron deficiency is common in women especially during dieting, weight management trials rarely examine the longitudinal impact of genetics on iron. This study examined the associations between the TMPRSS6 rs855791 polymorphism and iron indices at baseline and after a 12-month trial comparing two weight loss diets (higher-protein, higher-haem iron (HPHI) vs lower-protein, lower-haem iron (LPLI)). A total of 76 young overweight women (18-25y; BMI⩾27.5 kg/m(2)) were included at baseline, with 27 (HPHI: n=15; LPLI: n=12) completing the 12-month trial. At baseline, C allele homozygotes exhibited higher serum iron (P=0.047) and lower hepcidin (P=0.023) compared with T allele carriers. After 12 months, no genotypic differences were observed for ferritin and soluble transferrin receptor, although C homozygotes on HPHI showed higher serum iron and transferrin saturation (P<0.05). Results indicate that rs855791 can influence iron metabolism to some extent, but its impact on storage and functional iron status is small relative to dietary protein/iron manipulation.

Indexed as

Caloric RestrictionAdolescentAdultAllelesAnemia, Iron-DeficiencyBody Mass IndexCross-Sectional StudiesDietary ProteinsDiet, ReducingFerritinsGene FrequencyHepcidinsHumansIron, DietaryLongitudinal StudiesOverweightDietary ProteinsFerritinsHepcidinsIron, Dietary

Identifiers

PMID24801367
OpenAlexW2040043946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.