Sex: how malaria parasites get turned on.

Johan Ankarklev, Nicolas M B Brancucci, Ilana Goldowitz, Pierre-Yves Mantel, Matthias Marti

Abstract readComment

In one paragraph

Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine.Parasitology · 2016
Review
Plasmodium vivax gametocyte infectivity in sub-microscopic infections.Malaria journal · 2016
Article
Coalescent Times and Patterns of Genetic Diversity in Species with Facultative Sex: Effects of Gene Conversion, Population Structure, and Heterogeneity.Genetics · 2016
Article
An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development.Nature protocols · 2015
Article
ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata.PLoS neglected tropical diseases · 2015
Article

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Johan AnkarklevHarvard School of Public Health, Department of Immunology and Infectious Diseases, 665 Huntington Ave, Boston, MA 02115, USA.

Nicolas M B BrancucciHarvard School of Public Health, Department of Immunology and Infectious Diseases, 665 Huntington Ave, Boston, MA 02115, USA.

Ilana GoldowitzHarvard School of Public Health, Department of Immunology and Infectious Diseases, 665 Huntington Ave, Boston, MA 02115, USA.

Pierre-Yves MantelHarvard School of Public Health, Department of Immunology and Infectious Diseases, 665 Huntington Ave, Boston, MA 02115, USA.

Matthias MartiHarvard School of Public Health, Department of Immunology and Infectious Diseases, 665 Huntington Ave, Boston, MA 02115, USA. Electronic address: mmarti@hsph.harvard.edu.

Funding

Medical Research Council G0600230

6 · The paper itself

Abstract

The mechanisms underlying sexual stage switching in Plasmodium spp. have hitherto remained a mystery. However, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is essential for the initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.

Indexed as

AnimalsFemaleGene Expression RegulationGerm CellsMalariaMaleParasitesPlasmodium bergheiPlasmodium falciparumSexual DevelopmentTranscription, Genetic

Identifiers

PMID24801188

DOI10.1016/j.cub.2014.03.046

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.