ArticleEuropean journal of clinical pharmacology2014
Prevalence of suboptimal drug treatment in patients with and without multidose drug dispensing--a cross-sectional study.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Deprescribing in older patients with hyperpolypharmacy: a cluster-randomised trial in primary care.Age and ageing · 2026Trial
- Association between drug-specific indicators of prescribing quality and quality of drug treatment: a validation study.Pharmacoepidemiology and drug safety · 2015Trial
- Impacts of Outsourcing Medication Repackaging in Nursing Homes: Quality and Areas of Pharmacy-Nursing Collaboration.Pharmacy (Basel, Switzerland) · 2025Article
- Impact of electronic prescribing on medication changes in users of multidose drug dispensing.Exploratory research in clinical and social pharmacy · 2025Article
- Drug-related problems and associated factors among patients with kidney dysfunction at a tertiary hospital in southwestern Uganda: a prospective observational study.BMC nephrology · 2023Observational
- Observational
- Revisiting the inter-rater reliability of drug treatment assessments according to the STOPP/START criteria.British journal of clinical pharmacology · 2023Article
- Clinical relevance of potentially inappropriate medications and potential prescribing omissions according to explicit criteria-a validation study.European journal of clinical pharmacology · 2022Article
- Prevalence of potentially inappropriate medications among old people with major neurocognitive disorder in 2012 and 2017.BMC geriatrics · 2022Article
- Integrating medication risk management interventions into regular automated dose dispensing service of older home care clients - a systems approach.BMC geriatrics · 2021Article
- Using Technology-Supported Transfer of Care Systems: Informing Good Practice Recommendations.Pharmacy (Basel, Switzerland) · 2021Article
- A descriptive study of pain treatment and its follow-up in primary care of elderly patients after orthopaedic care.Journal of pharmaceutical health care and sciences · 2020Article
- Attitudes and behaviour towards psychotropic drug prescribing in Swedish primary care: a questionnaire study.BMC family practice · 2019Article
- Are multidose drug dispensing systems initiated for the appropriate patients?European journal of clinical pharmacology · 2018Article
- The experiences and beliefs of older people in Scottish very sheltered housing about using multi-compartment compliance aids.International journal of clinical pharmacy · 2018Article
- Multicompartment compliance aids in the community: the prevalence of potentially inappropriate medications.British journal of clinical pharmacology · 2017Article
- Clinical relevance of the STOPP/START criteria in hip fracture patients.European journal of clinical pharmacology · 2017Article
- Long-term use of proton pump inhibitors and prevalence of disease- and drug-related reasons for gastroprotection-a cross-sectional population-based study.Pharmacoepidemiology and drug safety · 2017Article
- Potentially inappropriate prescribing and adverse drug reactions in the elderly: a population-based study.European journal of clinical pharmacology · 2015Article
- Number of drugs in the medication list as an indicator of prescribing quality: a validation study of polypharmacy indicators in older hip fracture patients.European journal of clinical pharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to compare the prevalence of suboptimal drug treatment in older patients with and without multidose drug dispensing (MDD).
methodsIn 200 hip fracture patients (≥65 years of age), originally recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was compared between patients with and without MDD. Two specialist physicians independently assessed and then agreed on the quality of the drug treatment of each patient. Suboptimal drug treatment was defined as ≥1 STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) or ≥1 START (Screening Tool to Alert to Right Treatment) outcome assessed as clinically relevant after individual considerations had been made, i.e. over- or undertreatment (≥1 inappropriate and ≥1 missing drug, respectively).
resultsPatients with MDD (n=100) differed from patients without MDD (n=100) in several ways, for example by being older (87.6 vs. 81.5 years) and using more drugs (8.4 vs. 5.9 drugs). The total number (±standard deviation) of inappropriate and/or missing drugs per person was greater in MDD patients compared with patients without MDD (1.92±1.52 vs. 1.06±1.29, P<0.0001); MDD patients had an additional 0.77 inappropriate drugs and an additional 0.09 missing drugs per person. The prevalence of suboptimal drug treatment was greater in patients with MDD than in those without MDD (86 vs. 55%, P<0.0001). Logistic regression revealed that suboptimal drug treatment was 8.0 times as common in MDD patients, after adjustments for age, sex, number of drugs, cognition, and residence (95% confidence interval 2.4; 26.9). Corresponding figures for over- and undertreatment were 2.9 (1.1; 7.4) and 1.8 (0.8; 4.3), respectively.
conclusionsSuboptimal drug treatment, including over- and undertreatment, is more common in MDD patients than in patients who receive their drugs via ordinary prescriptions. The findings confirm safety concerns regarding quality of drug treatment in MDD patients.
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