ArticleHead & neck2015
Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes.
Article in Head & neck, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Article
- Moving from conventional to adaptive risk stratification for oropharyngeal cancer.Frontiers in oncology · 2024Review
- Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation.Head and neck pathology · 2023Article
- Machine learning driven index of tumor multinucleation correlates with survival and suppressed anti-tumor immunity in head and neck squamous cell carcinoma patients.Oral oncology · 2023Article
- Deployment of cisplatin in Veterans with oropharyngeal cancer: toxicity and impact on oncologic outcomes.Laryngoscope investigative otolaryngology · 2023Article
- HPV and Other Risk Factors Involved in Pharyngeal Neoplasm-Clinical and Morphopathological Correlations in the Southwestern Region of Romania.Pathogens (Basel, Switzerland) · 2023Article
- Prospective validation of diffusion-weighted MRI as a biomarker of tumor response and oncologic outcomes in head and neck cancer: Results from an observational biomarker pre-qualification study.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Observational
- Mutational profiles of head and neck squamous cell carcinomas based upon human papillomavirus status in the Veterans Affairs National Precision Oncology Program.Journal of cancer research and clinical oncology · 2023Article
- Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Article
- Article
- National trends in oropharyngeal cancer incidence and survival within the Veterans Affairs Health Care System.Head & neck · 2021Article
- Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma.BMC cancer · 2020Article
- Emotional disclosure and cognitive processing in couples coping with head and neck cancer.Journal of behavioral medicine · 2020Article
- High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung.Scientific reports · 2020Article
- Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting.Oral oncology · 2020Article
- CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer.Scientific reports · 2020Article
- Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil.Clinics (Sao Paulo, Brazil) · 2020Article
- A Hidden Epidemic of "Intermediate Risk" Oropharynx Cancer.Laryngoscope investigative otolaryngology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundA significant fraction of oropharyngeal squamous cell carcinoma (SCC) cases is associated with traditional carcinogens; in these patients, treatment response and clinical outcomes remain poor.
methodsWe evaluated patient, tumor, and treatment characteristics for 200 veterans with oropharyngeal SCC treated at the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) between 2000 and 2012.
resultsMost patients (77%) were white and heavy smokers. Twenty-seven patients required tracheostomy and 63 required gastrostomy placement during treatment. Overall survival (OS) at 5 years was 40%. Survival was impacted by T classification, treatment intensity, completion of treatment, and p16 tumor status. Almost 30% of patients were unable to complete a treatment regimen consistent with National Comprehensive Cancer Network (NCCN) guidelines.
conclusionOropharyngeal SCC in veterans is associated with traditional carcinogens and poor clinical outcomes. Despite heavy smoking exposure, p16 tumor status significantly impacts survival. Careful consideration must be given to improving treatment paradigms for this cohort given their limited tolerance for treatment escalation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.