Evidence map›Paper›PMID 24801071›Full record

ArticleEuropean heart journal2014

Risk stratification for sudden cardiac death: current status and challenges for the future.

Hein J J Wellens, Peter J Schwartz, Fred W Lindemans, Alfred E Buxton, Jeffrey J Goldberger, Stefan H Hohnloser, Heikki V Huikuri, Stefan Kääb, Maria Teresa La Rovere, Marek Malik and 6 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02175836 (Arrhythmia Prediction Trial and Risk Stratification in Heart Failure Patients - Athens.), which is not on this map. Cited by 167 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 5 pooled it
27.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02175836 unknown statusnot on this map

Arrhythmia Prediction Trial and Risk Stratification in Heart Failure Patients - Athens.

TypeobservationalSponsorUniversity of AthensRan2007 to 2019Enrolled500ConditionsMyocardial Infarction, Dilated Cardiomyopathy, Heart Failure
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 5 syntheses or guidelines pooled it, 402 citations in OpenAlex.

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  10. A review on wearable cardioverter-defibrillators in clinical practice for sudden cardiac death prevention and heart failure management.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 16 institutions in 8 countries.

Hein J J WellensCardiovascular Research Center, Maastricht, The Netherlands.
Peter J SchwartzIRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin, Milan, Italy peter.schwartz@unipv.it.
Fred W LindemansMedtronic Bakken Research Center, Maastricht, The Netherlands.
Alfred E BuxtonCardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jeffrey J GoldbergerDivision of Cardiology, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stefan H HohnloserDivision of Clinical Electrophysiology, Department of Cardiology, J. W. Goethe University, Frankfurt, Germany.
Heikki V HuikuriMedical Research Center Oulu, University and University Hospital of Oulu, Oulu, Finland.
Stefan KääbDepartment of Medicine I, University Hospital, Ludwig-Maximilians-University, Münich, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Münich Heart Alliance, Münich, Germany.
Maria Teresa La RovereDepartment of Cardiology, Fondazione 'Salvatore Maugeri', IRCCS, Istituto Scientifico di Montescano, Montescano, Pavia, Italy.
Marek MalikSt Paul's Cardiac Electrophysiology, University of London and Imperial College, London, UK.
Robert J MyerburgCardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Maarten L SimoonsThoraxcentrum, Erasmus MC, Cardiology, Rotterdam, The Netherlands.
Karl SwedbergUniversity of Gothenburg, Gothenburg, Sweden.
Jan TijssenDepartment of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Adriaan A VoorsUniversity Medical Center Groningen, Groningen, The Netherlands.
Arthur A WildeDepartment of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands Princess Al Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Beth Israel Deaconess Medical Center · USErasmus MC · NLFondazione Salvatore Maugeri · ITGoethe University Frankfurt · DEIRCCS Istituto Auxologico Italiano · ITKing Abdulaziz University · SALudwig-Maximilians-Universität München · DEMaastricht University · NLMedtronic (Netherlands) · NLNorthwestern University · USOulu University Hospital · FIUniversity Medical Center Groningen · NLUniversity of Amsterdam · NLUniversity of Gothenburg · SEUniversity of London · GBUniversity of Miami · US

Funding

British Heart Foundation PG/12/77/29857British Heart Foundation PG/13/54/30358
6 · The paper itself

Abstract

Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.

Indexed as

AgedArrhythmias, CardiacAutonomic Nervous System DiseasesBiomarkersDeath, Sudden, CardiacEarly DiagnosisElectrocardiographyFemaleForecastingGenetic TestingHeart FailureHeart Function TestsHumansMaleMiddle AgedPrognosisBiomarkersAutonomic nervous systemCardiac functionElectrical instabilityGeneticsRisk stratificationSudden cardiac death

Identifiers

PMID24801071
PMCPMC4076664
OpenAlexW2162846687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.