ArticleLasers in medical science2014
Comparative analysis of low-level laser therapy (660 nm) on inflammatory biomarker expression during the skin wound-repair process in young and aged rats.
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Should open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy.Lasers in medical science · 2018Pooled it
- Dose-response and efficacy of 904 nm photobiomodulation on diabetic foot ulcers healing: a randomized controlled trial.Lasers in medical science · 2024Trial
- Low-level laser therapy as an adjunct to conventional therapy in the treatment of diabetic foot ulcers.Lasers in medical science · 2017Trial
- Comparison of two power densities on the healing of palatal wounds after connective tissue graft removal: randomized clinical trial.Lasers in medical science · 2016Trial
- Age-related local versus systemic early phase wound healing dynamics following free gingival graft harvest.Journal of periodontology · 2026Article
- Effect of photobiomodulation therapy on the proliferation phase and wound healing in rats fed with an experimental hypoproteic diet.Lasers in medical science · 2021Article
- Light-emitting diode stimulates radiodermatitis recovery.Acta cirurgica brasileira · 2021Article
- Wound Photobiomodulation Treatment Outcomes in Animal Models.Journal of veterinary medicine · 2019Review
- The effects of transcutaneous low-level laser therapy on the skin healing process: an experimental model.Lasers in medical science · 2018Article
- Effect of photobiomodulation on connective tissue remodeling and regeneration of skeletal muscle in elderly rats.Lasers in medical science · 2018Article
- Photobiomodulation therapy action in wound repair skin induced in aged rats old: time course of biomarkers inflammatory and repair.Lasers in medical science · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wound-healing process plays an essential role in the protective response to epidermal injury by tissue regeneration. In the elderly, skin functions deteriorate as a consequence of morphological and structural changes. This study aimed to evaluate and compare the effect of low-level laser therapy (LLLT) in cutaneous wound healing in young and aged rats. A total of 60 male rats comprising 30 young (± 30 days) and 30 aged (± 500 days) was used. The animals were divided into four experimental groups and underwent skin wound and/or treatment with LLLT (660 nm, 30 mW, 1.07 W/cm(2), 0.028 cm(2), 72 J/cm(2), and 2 J). Analyses were conducted to verify the effects of LLLT in the tissue repair process, in the gene expression, and protein expression of TNF-α, IL-1β, and IL-10, obtained in skin wound model. Results showed that there were significant differences between the young control group and the aged control group and their respective treated groups (LLLT young and LLLT aged). We conclude that LLLT has shown to be effective in the treatment of skin wounds in young and aged animals at different stages of the tissue repair process, which suggests that different LLLT dosimetry should be considered in treatment of subjects of different ages. Further clinical trials are needed to confirm these findings in clinical settings.
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