Trial reportLasers in medical science2014
Low-level laser therapy to treat fibromyalgia.
Trial report in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic review.Lasers in medical science · 2026Pooled it
- Photobiomodulation and sleep quality: systematic review and meta-analysis.Lasers in medical science · 2026Pooled it
- Effects of Physical-Agent Pain Relief Modalities for Fibromyalgia Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Pain research & management · 2018Pooled it
- Effects of 36.5 Hz pulsed LASER acupuncture on pain and disease impact in fibromyalgia patients: A pilot randomized clinical trial.Clinical rheumatology · 2025Trial
- Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial.Lasers in medical science · 2018Trial
- Evaluation of the therapeutic effects of led (λ627 ± 10 nm) on the initial phase of ankle sprain treatment: a randomised placebo-controlled clinical trial.Lasers in medical science · 2018Trial
- Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment.Lasers in medical science · 2018Trial
- Low-level laser therapy and anesthetic infiltration for orofacial pain in patients with fibromyalgia: a randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2018Trial
- Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients.Lasers in medical science · 2016Trial
- Physical Modalities for the Treatment of Pain in Patients with Fibromyalgia.Mediterranean journal of rheumatology · 2025Review
- Electroceuticals: Unlocking the promise of therapies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Novel Therapies for Centralized Pain: a Brief Review.Current pain and headache reports · 2022Review
- Whole-body photobiomodulation therapy for chronic pain: a protocol for a feasibility trial.BMJ open · 2022Article
- Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies.International journal of molecular sciences · 2020Review
- The effectiveness and safety of electrotherapy in the management of fibromyalgia.Rheumatology international · 2020Review
- Acute low-level laser therapy effects on peripheral muscle strength and resistance in patients with fibromyalgia.Lasers in medical science · 2020Article
- Evaluation of the Therapeutic Effect of Low Level Laser in Controlling Low Back Pain: A Randomized Controlled Trial.Journal of lasers in medical sciences · 2020Article
- Photobiomodulation can alter mRNA levels cell death-related.Lasers in medical science · 2019Article
- The Use of Laser Therapy for Patients with Fibromyalgia: A Critical Literary Review.Journal of lasers in medical sciences · 2019Review
- Treatment of drug-resistant fibromyalgia symptoms using high-intensity laser therapy: a case-based review.Rheumatology international · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several clinical treatments have been proposed to manage symptoms of fibromyalgia. Low-level laser therapy (LLLT) may be a useful tool to treat this dysfunction. The aim of this study was to evaluate the effects of LLLT in patients with fibromyalgia. A placebo-controlled, randomized clinical trial was carried out with 20 patients divided randomly into either an LLLT group (n = 10) or a placebo group (n = 10). The LLLT group was treated with a GaAlAs laser (670 nm, 4 J/cm(2) on 18 tender points) three times a week over 4 weeks. Before and after treatment, patients were evaluated with the Fibromyalgia Impact Questionnaire (FIQ), McGill Pain Questionnaire, and visual analog scale (VAS). Data from the FIQ and McGill questionnaire for the treated and control groups were analyzed by paired t tests, and Wilcoxon tests were used to analyze data from the VAS. After LLLT or sham treatment, the number of tender points was significantly reduced in both groups (LLLT, p < 0.0001; placebo, p = 0.0001). However, all other fibromyalgia symptoms showed significant improvements after LLLT compared to placebo (FIQ, p = 0.0003; McGill, p = 0.0078; and VAS, p = 0.0020). LLLT provided relief from fibromyalgia symptoms in patients and should be further investigated as a therapeutic tool for management in fibromyalgia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.