ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Nature and extent of left/right axis defects in T(Wis) /T(Wis) mutant mouse embryos.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
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- Defects in intervertebral disc and spine during development, degeneration, and pain: New research directions for disc regeneration and therapy.Wiley interdisciplinary reviews. Developmental biology · 2019Review
- Functional comparison of distinctBiology open · 2018Article
- Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us?Journal of cardiovascular development and disease · 2017Review
- Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo.International journal of molecular sciences · 2017Article
- The Role of Cerl2 in the Establishment of Left-Right Asymmetries during Axis Formation and Heart Development.Journal of cardiovascular development and disease · 2017Review
- Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The T-box gene family: emerging roles in development, stem cells and cancer.Development (Cambridge, England) · 2014Review
- Mechanisms of left-right asymmetry and patterning: driver, mediator and responder.F1000prime reports · 2014Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMutations in the T-box gene Brachyury have well known effects on invagination of the endomesodermal layer during gastrulation, but the gene also plays a role in the determination of left/right axis determination that is less well studied. Previous work has implicated node morphology in this effect. We use the T(Wis) allele of Brachyury to investigate the molecular and morphological effects of the T locus on axis determination in the mouse.
resultsSimilar to embryos mutant for the T allele, T(Wis) /T(Wis) embryos have a high incidence of ventral and/or reversed heart looping. In addition, heterotaxia between the direction of heart looping and the direction of embryo turning is common. Scanning electron microscopy reveals defects in node morphology including irregularity, smaller size, and a decreased number of cilia, although the cilia appear morphologically normal. Molecular analysis shows a loss of perinodal expression of genes involved in Nodal signaling, namely Cer2, Gdf1, and Nodal itself. There is also loss of Dll1 expression, a key component of the Notch signaling pathway, in the presomitic mesoderm.
conclusionsMorphological abnormalities of the node as well as disruptions of the molecular cascade of left/right axis determination characterize T(Wis) /T(Wis) mutants. Decreased Notch signaling may account for both the morphological defects and the absence of expression of genes in the Nodal signaling pathway.
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