ReviewCurrent opinion in neurobiology2014
Brains in metamorphosis: reprogramming cell identity within the central nervous system.
Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2.Stem cell reports · 2023Article
- Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.PLoS biology · 2023Article
- Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way.Cell reports · 2018Article
- MicroRNA-Directed Neuronal Reprogramming as a Therapeutic Strategy for Neurological Diseases.Molecular neurobiology · 2018Review
- Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord.Cell and tissue research · 2018Review
- Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes.Stem cell reports · 2017Article
- Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?Hearing research · 2017Review
- Article
- The essentiality of non-coding RNAs in cell reprogramming.Non-coding RNA research · 2017Review
- Mismatch of Synaptic Patterns between Neurons Produced in Regeneration and during Development of the Vertebrate Retina.Current biology : CB · 2016Article
- Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.The Journal of clinical investigation · 2016Article
- Article
- Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.NPJ aging and mechanisms of disease · 2016Review
- Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.Cell stem cell · 2015Review
- Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- SOX2 reprograms resident astrocytes into neural progenitors in the adult brain.Stem cell reports · 2015Article
- Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease.Cell death discovery · 2015Article
- Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.Stem cell reports · 2014Article
- The stability of memories during brain remodeling: A perspective.Communicative & integrative biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
During embryonic development, uncommitted pluripotent cells undergo progressive epigenetic changes that lock them into a final differentiated state. Can mammalian cells change identity within the living organism? Direct lineage reprogramming of cells has attracted attention as a means to achieve organ regeneration. However, it is unclear whether cells in the CNS are endowed with the plasticity to reprogram. Neurons in particular are considered among the most immutable cell types, able to retain their class-specific traits for the lifespan of the organism. Here we focus on two experimental paradigms, glia-to-neuron and neuron-to-neuron conversion, to consider how lineage reprogramming has challenged the notion of CNS immutability, paving the way for the application of reprogramming strategies to reshape neurons and circuits in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.