ArticleBioMed research international2014
NMR-based metabolomic profiling of overweight adolescents: an elucidation of the effects of inter-/intraindividual differences, gender, and pubertal development.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Physical Activity and Metabolic Alterations in Children and Adolescents Across Different Weight Groups: A Systematic Review.European journal of sport science · 2026Pooled it
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- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat lossFrontiers in molecular biosciences · 2023Article
- Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men.Metabolites · 2022Article
- Research in the Field of Exercise and Metabolomics: A Bibliometric and Visual Analysis.Metabolites · 2022Review
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- Spectroscopic and Molecular Methods to Differentiate Gender in Immature Date Palm (Plants (Basel, Switzerland) · 2021Article
- Influence of Sex on Urinary Organic Acids: A Cross-Sectional Study in Children.International journal of molecular sciences · 2020Article
- Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.Metabolites · 2019Article
- Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity.Environment international · 2019Article
- Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome.Nutrients · 2019Article
- Nonfermented milk and other dairy products: associations with all-cause mortality.The American journal of clinical nutrition · 2017Article
- Article
- Assessment of metabolic phenotypic variability in children's urine usingScientific reports · 2017Article
- Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats.European journal of nutrition · 2017Article
- Metabolomics to Explore Impact of Dairy Intake.Nutrients · 2015Review
- Plasma Metabolic Profiles in Women are Menopause Dependent.PloS one · 2015Article
- Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.Metabolites · 2014Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma and urine metabolome of 192 overweight 12-15-year-old adolescents (BMI of 25.4 ± 2.3 kg/m(2)) were examined in order to elucidate gender, pubertal development measured as Tanner stage, physical activity measured as number of steps taken daily, and intra-/interindividual differences affecting the metabolome detected by proton NMR spectroscopy. Higher urinary excretion of citrate, creatinine, hippurate, and phenylacetylglutamine and higher plasma level of phosphatidylcholine and unsaturated lipid were found for girls compared with boys. The results suggest that gender differences in the metabolome are being commenced already in childhood. The relationship between Tanner stage and the metabolome showed that pubertal development stage was positively related to urinary creatinine excretion and negatively related to urinary citrate content. No relations between physical activity and the metabolome could be identified. The present study for the first time provides comprehensive information about associations between the metabolome and gender, pubertal development, and physical activity in overweight adolescents, which is an important subject group to approach in the prevention of obesity and life-style related diseases. While this study is preliminary, these results may have the potential to translate into clinical applicability upon further investigations; if biomarkers for Tanner stage can be established, these might be used for identification of individuals susceptible to an early pubertal development.
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