Evidence map›Paper›PMID 24800217›Full record

ArticleBioMed research international2014

Engineered tumor cell apoptosis monitoring method based on dynamic laser tweezers.

Yuquan Zhang, Xiaojing Wu, Changjun Min, Siwei Zhu, H Paul Urbach, Xiaocong Yuan

Abstract read
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuquan ZhangKey Laboratory of Optoelectronic Information Science & Technology, Institute of Modern Optics, Nankai University, Ministry of Education of China, Tianjin 300071, China.
Xiaojing WuInstitute of Oncology, Tianjin Union Medicine Centre, Tianjin 300121, China.
Changjun MinKey Laboratory of Optoelectronic Information Science & Technology, Institute of Modern Optics, Nankai University, Ministry of Education of China, Tianjin 300071, China.
Siwei ZhuInstitute of Oncology, Tianjin Union Medicine Centre, Tianjin 300121, China.
H Paul UrbachOptics Research Group, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
Xiaocong YuanInstitute of Micro & Nano Optics, Shenzhen University, Shenzhen 518060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring the cells' apoptosis progression could provide a valuable insight into the temporal events that initiate cell death as well as the potential for rescue of apoptotic cells. In this paper, we engineered a novel and robust method for monitoring apoptosis of tumor cells based on dynamic laser tweezers, using A549 and HeLa cell line as typical samples. The entire experiment can be completed in a few hours with small amount of fluid sample, presenting great advantages of celerity, microscaled measurement, and label-free explorations without perturbing experimental conditions in combination with other probes. Validity and stability of this method are verified experimentally in terms of physical parameters of the system. The proposed technique has great potential in improving cancer treatment by monitoring the objective efficacy of tumor cell killing.

Indexed as

Optical TweezersAntineoplastic AgentsApoptosisCell Line, TumorCisplatinEquipment DesignEquipment Failure AnalysisFlow CytometryHeLa CellsHumansMicrofluidic Analytical TechniquesMicromanipulationNeoplasms, ExperimentalAntineoplastic AgentsCisplatin

Identifiers

PMID24800217
PMCPMC3988732

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.