Evidence map›Paper›PMID 24800167›Full record

ArticleOncoimmunology2014

Why should we need the gut microbiota to respond to cancer therapies?

Sophie Viaud, Romain Daillère, Takahiro Yamazaki, Patricia Lepage, Ivo Boneca, Romina Goldszmid, Giorgio Trinchieri, Laurence Zitvogel

Abstract read
In one paragraph

Article in Oncoimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Fecal microbiome in dogs with lymphoid and nonlymphoid tumors.Journal of veterinary internal medicine · 2023
    Article
  3. The interplay between anticancer challenges and the microbial communities from the gut.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Review
  4. Review
  5. Article
  6. Article
  7. Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie ViaudInstitut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
Romain DaillèreInstitut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
Takahiro YamazakiInstitut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France.
Patricia LepageInstitut National de la Recherche Agronomique, Micalis; UMR1319; Jouy-en-Josas, France ; AgroParisTech; Micalis; UMR1319; Jouy-en-Josas, France.
Ivo BonecaUnit of Biology and Genetics of the Bacterial Cell Wall; Institut Pasteur; Paris, France ; Institut National de la Santé et de la Recherche Médicale; Group Avenir; Paris, France.
Romina GoldszmidCancer and Inflammation Program; National Cancer Institute; Frederick, MD USA.
Giorgio TrinchieriCancer and Inflammation Program; National Cancer Institute; Frederick, MD USA.
Laurence ZitvogelInstitut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Centre d'Investigation Clinique Biothérapie CICBT 507; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.

Funding

Role of mouse microbiome in cancer and inflammationZIABC011153 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$22.0M
Role of inflammation, innate resistance, and immunity in carcinogenesis.ZIABC010793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$16.8M
6 · The paper itself

Abstract

Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pT

Indexed as

antibioticscancerchemotherapyGram-positive bacteriaimmunomodulatory regimenmicrobiotapTh17

Identifiers

PMID24800167
PMCPMC4006853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.