ArticleCytoJournal2014
The state of cell block variation and satisfaction in the era of molecular diagnostics and personalized medicine.
Article in CytoJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Cellularity of Routinely Prepared Cell Blocks: Insights From an International Study.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Observational
- A Multicenter Investigation of Minimally Invasive Sample Processing and the Pre-Analytic Assessment of NSCLC Small Biopsy Specimens for Molecular Testing.Diagnostics (Basel, Switzerland) · 2026Article
- Modified plasma-thrombin method using patient-derived plasma for cell block preparation in endobronchial ultrasound-guided transbronchial fine-needle aspiration.Journal of pathology and translational medicine · 2025Article
- Nationwide differences in cytology fixation and processing methods and their impact on interlaboratory variation in PD-L1 positivity.Virchows Archiv : an international journal of pathology · 2023Article
- Optimization of pre-analytical and analytical steps for DNA and RNA analysis of fresh cytology samples.Cancer medicine · 2022Article
- Evaluation of Cytologic Sample Preparations for Compatibility With Nucleic Acid Analysis.American journal of clinical pathology · 2022Article
- PD-L1 and beyond: Immuno-oncology in cytopathology.Cytopathology : official journal of the British Society for Clinical Cytology · 2021Review
- Evaluating Estrogen Receptor Immunohistochemistry on Cell Blocks From Breast Cancer Patients in a Low-Resource Setting.Archives of pathology & laboratory medicine · 2021Article
- Which are the limiting factors in lung tissue sampling and diagnostic accuracy for a new Interventional Pulmonology Unit? From expert consensus-based evidence to results of a new-born Unit.Journal of thoracic disease · 2021Article
- Cell-blocks and other ancillary studies (including molecular genetic tests and proteomics).CytoJournal · 2021Review
- Cytologic evaluation of p16 staining in head and neck squamous cell carcinoma in CytoLyt versus formalin-fixed material.Cancer cytopathology · 2019Article
- CytoLyt fixation significantly inhibits MIB1 immunoreactivity whereas alternative Ki-67 clone 30-9 is not susceptible to the inhibition: Critical diagnostic implications.Cancer cytopathology · 2019Article
- Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- CellBlockistry: Chemistry and art of cell-block making - A detailed review of various historical options with recent advances.CytoJournal · 2019Review
- Novel Modification of HistoGel-Based Cell Block Preparation Method: Improved Sufficiency for Molecular Studies.Archives of pathology & laboratory medicine · 2018Article
- Optimizing Workflows and Processing of Cytologic Samples for Comprehensive Analysis by Next-Generation Sequencing: Memorial Sloan Kettering Cancer Center Experience.Archives of pathology & laboratory medicine · 2016Article
- Preparation of compact agarose cell blocks from the residues of liquid-based cytology samples.Korean journal of pathology · 2014Article
- High-quality endoscopic ultrasound-guided fine needle aspiration tissue acquisition.Advances in therapy · 2014Review
- Development of a Cost-effective Method for Cell Block Preparation: A Simple Way of Tumor Representation.Journal of cytologyArticle
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIn the recent past, algorithms and recommendations to standardize the morphological, immunohistochemical and molecular classification of lung cancers on cytology specimens have been proposed, and several organizations have recommended cell blocks (CBs) as the preferred modality for molecular testing. Based on the literature, there are several different techniques available for CB preparation-suggesting that there is no standard. The aim of this study was to conduct a survey of CB preparation techniques utilized in various practice settings and analyze current issues, if any. MATERIALS AND
methodsA single E-mail with a link to an electronic survey was distributed to members of the American Society of Cytopathology and other pathologists. Questions pertaining to the participants' practice setting and CBs-volume, method, quality and satisfaction-were included.
resultsOf 95 respondents, 90/95 (94%) completed the survey and comprise the study group. Most participants practice in a community hospital/private practice (44%) or academic center (41%). On average, 14 CBs (range 0-50; median 10) are prepared by a laboratory daily. Over 10 methods are utilized: Plasma thrombin (33%), HistoGel (27%), Cellient automated cell block system (8%) and others (31%) respectively. Forty of 90 (44%) respondents are either unsatisfied or sometimes satisfied with their CB quality, with low-cellular yield being the leading cause of dissatisfaction. There was no statistical significance between the three most common CB preparation methods and satisfaction with quality. DISCUSSION: Many are dissatisfied with their current method of CB preparation, and there is no consistent method to prepare CBs. In today's era of personalized medicine with an increasing array of molecular tests being applied to cytological specimens, there is a need for a standardized protocol for CB optimization to enhance cellularity.
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Registered trials
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