ArticleIranian journal of reproductive medicine2014
Effect of aqueous and hydro-alcoholic extracts of lettuce (Lactuca sativa) seed on testosterone level and spermatogenesis in NMRI mice.
Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Forskolin Improves Male Reproductive Complications Caused by Hyperglycemia in Type 2 Diabetic Rats.International journal of fertility & sterility · 2023Article
- Effect ofJournal of diabetes and metabolic disorders · 2021Article
- The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats.Clinical and experimental reproductive medicine · 2020Article
- Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies.Metabolites · 2020Article
- Toxic Effects of Chronic Exposure to High-Fat Diet and Arsenic on the Reproductive System of the Male Mouse.Journal of family & reproductive health · 2019Article
- Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice.International journal of reproductive biomedicine · 2016Article
- Sodium metabisulfite-induced changes on testes, spermatogenesis and epididymal morphometric values in adult rats.International journal of reproductive biomedicine · 2015Article
- Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice.The world journal of men's health · 2014Article
- Effects of exendin-4 on male reproductive parameters of d-galactose induced aging mouse model.The world journal of men's health · 2014Article
- The effects of lettuce extract on the level of T4, memory and nerve conduction velocity in male rats.Avicenna journal of phytomedicineArticle
- Effects of Hydro-alcoholic Extract from Arctium lappa L. (Burdock) Root on Gonadotropins, Testosterone, and Sperm Count and Viability in Male Mice with Nicotinamide/ Streptozotocin-Induced Type 2 Diabetes.The Malaysian journal of medical sciences : MJMSArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne of the considerable uses of lettuce (Lactuca sativa) seed in traditional medicine has been to reduce semen, sperm and sexuality.
objectiveThe aim of this study was to investigate the effects of aqueous and hydro-alcoholic extracts of lettuce seed on testosterone level and spermatogenesis. MATERIALS AND
methodsIn this experimental study 24 adult male NMRI mice weighing 20-25gr were purchased. Animals were randomly divided into 4 groups: controls, hydro-alcoholic (200 mg/kg) and aqueous extracts (50, 100mg/kg). The extracts were injected intraperitoneally once a day for 10 consecutive days. 2 weeks after the last injection, the mice were anaesthetized by ether and after laparatomy blood was collected from the heart to determine testosterone by ELISA assay kit. Then testis and cauda epididymis of all animals were removed for analyzing testis morphology and sperm count and viability.
resultsTestis weight in hydro-alcoholic and aqueous extracts 100 mg/kg (p=0.001) and aqueous extract 50 mg/kg (p=0.008) groups was increased. Sperm viability in hydro-alcoholic (p=0.001) and aqueous extracts 50 (p=0.026), 100 mg/kg (p=0.045) groups was decreased, Also the results showed a significant decrease in sperm count in hydro-alcoholic (p=0.035) and aqueous extracts 50 mg/kg (p=0.006) groups in comparison with control group. Also there was a significant increase in serum level of testosterone in aqueous extract 50 mg/kg group in comparison with control (p=0.002) hydro-alcoholic (p=0.001) and aqueous extracts 100 mg/kg (p=0.003) groups.
conclusionPresent results demonstrated that hydro-alcoholic and aqueous 50 mg/kg extracts of lettuce seed have antispermatogenic effects, also aqueous extract 50 mg/kg increased serum level of testosterone in mice. Therefore we can suggest that lettuce seed could be a potential contraceptive agent. This article extracted from M.Sc. student research project. (Ali Akbar Oroojan).
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24799863PMC4009587W1779694558What OpenQuestion holds
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