Evidence map›Paper›PMID 24799855›Full record

ArticleIranian journal of reproductive medicine2014

Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization/ intracytoplasmic sperm injection: A randomized clinical trial.

Afsoon Zarei, Mohammad Ebrahim Parsanezhad, Masoumeh Younesi, Saeed Alborzi, Jaleh Zolghadri, Alamtaj Samsami, Sedigheh Amooee, Shahintaj Aramesh

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01986374 (Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation), which is not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01986374 nacompletednot on this map

Intrauterine Injection of Human Chorionic Gonadotropin to Enhance Embryo Implantation

TypeinterventionalSponsorServy Massey Fertility InsitituteRan2013 to 2016Enrolled75ConditionsInfertilityArmsHCG is introduced
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  17. Effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on pregnancy rate: A prospective randomized study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Afsoon ZareiInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ebrahim ParsanezhadDepartment of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoumeh YounesiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Saeed AlborziInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jaleh ZolghadriInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Alamtaj SamsamiInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sedigheh AmooeeInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahintaj ArameshInfertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe direct effect of hCG on the human endometrium was studied several times.

objectiveThe objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET). MATERIALS AND

methodsIn this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250μg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups.

resultsPatients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively.

conclusionIntrauterine injection of 250μg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles. REGISTRATION ID IN IRCT: IRCT2012121711790N1 This article extracted from fellowship course thesis. (Masoumeh Younesi).

Indexed as

Implantation rateIntracytoplasmic sperm injection (ICSI)In vitro fertilization (IVF)Pregnancy rateRecombinant human chorionic gonadotropin (rhCG)

Identifiers

PMID24799855
PMCPMC4009584
OpenAlexW1511905210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.