ArticleProceedings of the National Academy of Sciences of the United States of America2014
Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 46 citations in OpenAlex.
- Electrical Control of the Transduction Channels' Gating Force in Mechanosensory Hair Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.Scientific reports · 2024Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Deiters Cells Act as Mechanical Equalizers for Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inferring entropy production rate from partially observed Langevin dynamics under coarse-graining.Physical chemistry chemical physics : PCCP · 2022Article
- Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.Biophysical journal · 2021Article
- Kinetic Membrane Model of Outer Hair Cells.Biophysical journal · 2021Article
- Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea.eLife · 2019Article
- SNARE machinery is optimized for ultrafast fusion.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.Science advances · 2019Article
- Travelling waves and tonotopicity in the inner ear: a historical and comparative perspective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Friction from Transduction Channels' Gating Affects Spontaneous Hair-Bundle Oscillations.Biophysical journal · 2018Article
- Physiological Preparation of Hair Cells from the Sacculus of the American Bullfrog (Rana catesbeiana).Journal of visualized experiments : JoVE · 2017Article
- Energy Output from a Single Outer Hair Cell.Biophysical journal · 2016Article
- Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla.Nature communications · 2016Article
- Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway.Cell proliferation · 2015Article
- Control of a hair bundle's mechanosensory function by its mechanical load.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.Biophysical journal · 2015Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing starts when sound-evoked mechanical vibrations of the hair-cell bundle activate mechanosensitive ion channels, giving birth to an electrical signal. As for any mechanical system, friction impedes movements of the hair bundle and thus constrains the sensitivity and frequency selectivity of auditory transduction. Friction is generally thought to result mainly from viscous drag by the surrounding fluid. We demonstrate here that the opening and closing of the transduction channels produce internal frictional forces that can dominate viscous drag on the micrometer-sized hair bundle. We characterized friction by analyzing hysteresis in the force-displacement relation of single hair-cell bundles in response to periodic triangular stimuli. For bundle velocities high enough to outrun adaptation, we found that frictional forces were maximal within the narrow region of deflections that elicited significant channel gating, plummeted upon application of a channel blocker, and displayed a sublinear growth for increasing bundle velocity. At low velocity, the slope of the relation between the frictional force and velocity was nearly fivefold larger than the hydrodynamic friction coefficient that was measured when the transduction machinery was decoupled from bundle motion by severing tip links. A theoretical analysis reveals that channel friction arises from coupling the dynamics of the conformational change associated with channel gating to tip-link tension. Varying channel properties affects friction, with faster channels producing smaller friction. We propose that this intrinsic source of friction may contribute to the process that sets the hair cell's characteristic frequency of responsiveness.
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