Evidence map›Paper›PMID 24799501›Full record

ArticleThe Journal of experimental medicine2014

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.

Gareth R Williams, Kaat Fierens, Stephen G Preston, Daniel Lunn, Oliwia Rysnik, Sofie De Prijck, Mirjam Kool, Hannah C Buckley, Bart N Lambrecht, Dermot O'Hare and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. LDH as an adjuvant makesIranian journal of basic medical sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
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  11. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Gareth R WilliamsChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UKChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Kaat FierensLaboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium.
Stephen G PrestonChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Daniel LunnChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Oliwia RysnikChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Sofie De PrijckLaboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium.
Mirjam KoolLaboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, Netherlands.
Hannah C BuckleyChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UKChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Bart N LambrechtLaboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital and Flanders Institute for Biotechnology (VIB) Inflammation Research Center, University of Ghent, 9000 Ghent, Belgium Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, Netherlands Bart.Lambrecht@ugent.be.
Dermot O'HareChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.
Jonathan M AustynChemistry Research Laboratory, Department of Chemistry; Nuffield Department of Surgical Sciences, John Radcliffe Hospital; and Department of Statistics; University of Oxford, Oxford OX1 2JD, England, UK.

Funding

Medical Research Council G0802620
6 · The paper itself

Abstract

There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. We show that structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, we find that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesized LDHs to be predicted in advance from these three parameters alone. We also show that mouse antigen-specific antibody responses in vivo and human macrophage responses in vitro are controlled by the same properties, suggesting they may control diverse responses at both individual component and global levels of immunity. This study demonstrates that immunity can be determined purely by chemistry and opens the possibility of rational manipulation of immunity for therapeutic purposes.

Indexed as

AnimalsAntibodiesAntibody FormationCells, CulturedCrystallizationCytokinesDendritic CellsEnzyme-Linked Immunosorbent AssayHumansHydroxidesMacrophagesMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionMultivariate AnalysisOvalbuminAntibodiesCytokinesHydroxidesOvalbumin

Identifiers

PMID24799501
PMCPMC4042647

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.