ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014
Pattern of frequent but nontargeted pharmacologic thromboprophylaxis for hospitalized patients with cancer at academic medical centers: a prospective, cross-sectional, multicenter study.
Abstract readMulticenter Study
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Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17citing papers in PubMed, 2 pooled it
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta-analysis.Journal of thrombosis and haemostasis : JTH · 2022Pooled it
- A systematic review of mobility/immobility in thromboembolism risk assessment models for hospitalized patients.Journal of thrombosis and thrombolysis · 2017Pooled it
- Improvement of appropriate pharmacological prophylaxis in hospitalised cancer patients with a multiscreen e-alert system: a single-centre experience.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Trial
- Modification and validation of the Padua prediction score for assessing the risk of venous thromboembolism in medical inpatients: a case-control study.Clinics (Sao Paulo, Brazil) · 2026Article
- Epidemiology of Cancer-Associated Venous Thromboembolism Across the United States.American journal of hematology · 2026Article
- Preferences Among Expert Physicians in Areas of Uncertainty in Venous Thromboembolism Management: Results from a Multiple-Choice Questionnaire.Journal of clinical medicine · 2025Article
- Review
- The Saudi Consensus for the Management of Cancer-Associated Thromboembolism: A Modified Delphi-Based Study.TH open : companion journal to thrombosis and haemostasis · 2023Article
- Assessment of adherence to cancer-associated venous thromboembolism guideline and pharmacist's impact on anticoagulant therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Prediction and Prevention of Cancer-Associated Thromboembolism.The oncologist · 2021Review
- Cancer associated thrombosis and mortality in patients with cancer stratified by khorana score risk levels.Cancer medicine · 2020Article
- Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients: a prospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Observational
- Differences in Venous Thromboembolism Prevention and Outcome between Hospitalized Patients with Solid and Hematologic Malignancies.TH open : companion journal to thrombosis and haemostasis · 2019Article
- Insights into venous thromboembolism prevention in hospitalized cancer patients: Lessons from a prospective study.PloS one · 2018Article
- Predicting risk of venous thromboembolism in hospitalized cancer patients: Utility of a risk assessment tool.American journal of hematology · 2017Article
- Cancer and Venous Thromboembolic Disease: A Review.The oncologist · 2017Review
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Authors and funding
15 authors.
Jeffrey I ZwickerJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH. jzwicker@bidmc.harvard.edu.
Adam RojanJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Federico CampigottoJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Nadia RehmanJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Renee FunchesJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Gregory ConnollyJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Jonathan WebsterJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Anita AggarwalJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Dalia MobarekJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Charles FaselisJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Donna NeubergJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Frederick R RicklesJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Ted WunJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Michael B StreiffJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Alok A KhoranaJeffrey I. Zwicker, Adam Rojan, and Renee Funches, Beth Israel Deaconess Medical Center and Harvard Medical School; Federico Campigotto and Donna Neuberg, Dana-Farber Cancer Institute, Boston, MA; Nadia Rehman and Ted Wun, University of California at Davis School of Medicine; Nadia Rehman and Ted Wun, VA Northern California Health Care System, Sacramento, CA; Gregory Connolly, University of Rochester Medical Center, Rochester, NY; Jonathan Webster and Michael B. Streiff, Johns Hopkins University School of Medicine, Baltimore, MD; Anita Aggarwal, Dalia Mobarek, Charles Faselis, and Frederick R. Rickles, Veterans Administration Medical Center and The George Washington University, Washington, DC; and Alok A. Khorana, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH.
Funding
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4MNCATS NIH HHS UL1 TR000170
Abstract
purposeHospitalized patients with cancer are considered to be at high risk for venous thromboembolism (VTE). Despite strong recommendations in numerous clinical practice guidelines, retrospective studies have shown that pharmacologic thromboprophylaxis is underutilized in hospitalized patients with cancer. PATIENTS AND
methodsWe conducted a prospective, cross-sectional study of hospitalized patients with cancer at five academic hospitals to determine prescription rates of thromboprophylaxis and factors influencing its use during hospitalization.
resultsA total of 775 patients with cancer were enrolled across five academic medical centers. Two hundred forty-seven patients (31.9%) had relative contraindications to pharmacologic prophylaxis. Accounting for contraindications to anticoagulation, the overall rate of pharmacologic thromboprophylaxis was 74.2% (95% CI, 70.4% to 78.0%; 392 of 528 patients). Among the patients with cancer without contraindications for anticoagulation, individuals hospitalized with nonhematologic malignancies were significantly more likely to receive pharmacologic thromboprophylaxis than those with hematologic malignancies (odds ratio [OR], 2.34; 95% CI, 1.43 to 3.82; P=.007). Patients with cancer admitted for cancer therapy were significantly less likely to receive pharmacologic thromboprophylaxis than those admitted for other reasons (OR, 0.37; 95% CI, 0.22 to 0.61; P<.001). Sixty-three percent of patients with cancer classified as low risk, as determined by the Padua Scoring System, received anticoagulant thromboprophylaxis. Among the 136 patients who did not receive anticoagulation, 58.8% were considered to be high risk by the Padua Scoring System.
conclusionWe conclude that pharmacologic thromboprophylaxis is frequently administered to hospitalized patients with cancer but that nearly one third of patients are considered to have relative contraindications for prophylactic anticoagulation. Pharmacologic thromboprophylaxis in hospitalized patients with cancer is commonly prescribed without regard to the presence or absence of concomitant risk factors for VTE.
Indexed as
Practice Patterns, Physicians'Academic Medical CentersAdolescentAdultAgedAged, 80 and overAnticoagulantsCross-Sectional StudiesFemaleHospitalizationHumansMaleMiddle AgedNeoplasmsProspective StudiesThromboembolismAnticoagulants
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