Evidence map›Paper›PMID 24799431›Full record

ArticleNucleic acids research2014

PredictProtein--an open resource for online prediction of protein structural and functional features.

Guy Yachdav, Edda Kloppmann, Laszlo Kajan, Maximilian Hecht, Tatyana Goldberg, Tobias Hamp, Peter Hönigschmid, Andrea Schafferhans, Manfred Roos, Michael Bernhofer and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 321 papers.

0numbers the graph read from it
0cells of the map it votes in
321citing papers in PubMed
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

321 citing papers in PubMed, 626 citations in OpenAlex.

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  13. Prediction of Intrinsic Disorder Functions with DEPICTER2.Methods in molecular biology (Clifton, N.J.) · 2025
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  15. Modeling protein motions through reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  16. Impact ofJournal of diabetes and metabolic disorders · 2024
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  19. Integrating physiological and multi-omics methods to elucidate heat stress tolerance for sustainable rice production.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024
    Review
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261 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 6 countries.

Guy YachdavDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany Biosof LLC, New York, NY 10001, USA TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), TUM (Technische Universität München), Garching/Munich 85748, Germany gyachdav@rostlab.org.
Edda KloppmannDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, New York, NY 10032, USA.
Laszlo KajanDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Maximilian HechtDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), TUM (Technische Universität München), Garching/Munich 85748, Germany.
Tatyana GoldbergDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany TUM Graduate School, Center of Doctoral Studies in Informatics and its Applications (CeDoSIA), TUM (Technische Universität München), Garching/Munich 85748, Germany.
Tobias HampDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Peter HönigschmidDepartment of Genome Oriented Bioinformatics, Technische Universität München, Wissenschaftszentrum Weihenstephan, Freising 85354, Germany.
Andrea SchafferhansDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Manfred RoosDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Michael BernhoferDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Lothar RichterDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany.
Haim AshkenazyThe Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel.
Marco PuntaWellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK Institute for Food and Plant Sciences WZW-Weihenstephan, Alte Akademie 8, Freising 85350, Germany.
Avner SchlessingerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SD, UK.
Yana BrombergBiosof LLC, New York, NY 10001, USA Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Reinhard SchneiderDepartment of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, USA.
Gerrit VriendLuxembourg University & Luxembourg Centre for Systems Biomedicine, 4362 Belval, Luxembourg.
Chris SanderCMBI, NCMLS, Radboudumc Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.
Nir Ben-TalComputational Biology Program, Memorial Sloan Kettering Cancer Center, New York, 10065 NY, USA.
Burkhard RostDepartment of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany Biosof LLC, New York, NY 10001, USA New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, New York, NY 10032, USA The Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel Department of Biochemistry and Molecular Biophysics & New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, New York, NY 10032, USA Institute for Advanced Study (TUM-IAS), Garching/Munich 85748, Germany.
Technical University of Munich · DEEuropean Bioinformatics Institute · GBIcahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USRadboud University Nijmegen · NLRutgers, The State University of New Jersey · USTel Aviv University · ILUniversity of Luxembourg · LUWeihenstephan-Triesdorf University of Applied Sciences · DEWellcome Sanger Institute · GB

Funding

Structural Genomics on Membrane ProteinsU54GM095315 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ROST, BURKHARD · 2010 to 2014
$15.2M
NIGMS NIH HHS U54 GM095315
6 · The paper itself

Abstract

PredictProtein is a meta-service for sequence analysis that has been predicting structural and functional features of proteins since 1992. Queried with a protein sequence it returns: multiple sequence alignments, predicted aspects of structure (secondary structure, solvent accessibility, transmembrane helices (TMSEG) and strands, coiled-coil regions, disulfide bonds and disordered regions) and function. The service incorporates analysis methods for the identification of functional regions (ConSurf), homology-based inference of Gene Ontology terms (metastudent), comprehensive subcellular localization prediction (LocTree3), protein-protein binding sites (ISIS2), protein-polynucleotide binding sites (SomeNA) and predictions of the effect of point mutations (non-synonymous SNPs) on protein function (SNAP2). Our goal has always been to develop a system optimized to meet the demands of experimentalists not highly experienced in bioinformatics. To this end, the PredictProtein results are presented as both text and a series of intuitive, interactive and visually appealing figures. The web server and sources are available at http://ppopen.rostlab.org.

Indexed as

Protein ConformationSoftwareAmino Acid SubstitutionBinding SitesGene OntologyInternetIntrinsically Disordered ProteinsMembrane ProteinsMutationProtein Interaction MappingProteinsSequence AlignmentSequence Analysis, ProteinSequence Homology, Amino AcidIntrinsically Disordered ProteinsMembrane ProteinsProteins

Identifiers

PMID24799431
PMCPMC4086098
OpenAlexW2154479185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.