ArticleObesity (Silver Spring, Md.)2014
Reversible hyperphagia and obesity in rats with gastric bypass by central MC3/4R blockade.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Meal Patterns and Food Choices of Female Rats Fed a Cafeteria-Style Diet Are Altered by Gastric Bypass Surgery.Nutrients · 2021Article
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.Molecular metabolism · 2020Article
- Gastric bypass surgery in lean adolescent mice prevents diet-induced obesity later in life.Scientific reports · 2019Article
- Does gastric bypass surgery change body weight set point?International journal of obesity supplements · 2016Review
- Eating in mice with gastric bypass surgery causes exaggerated activation of brainstem anorexia circuit.International journal of obesity (2005) · 2016Article
- Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice.Obesity (Silver Spring, Md.) · 2016Article
- RYGB progressively increases avidity for a low-energy, artificially sweetened diet in female rats.Appetite · 2016Article
- The Use of Rat and Mouse Models in Bariatric Surgery Experiments.Frontiers in nutrition · 2016Review
- Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.The Journal of clinical investigation · 2015Review
- The physiology underlying Roux-en-Y gastric bypass: a status report.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo test the commonly held assumption that gastric bypass surgery lowers body weight because it limits the ability to eat large amounts of food.
methodsCentral melanocortin signaling was blocked by ICV infusion of the melanocortin-3/4 receptor antagonist SHU9119 for 14 days in rats whose high-fat diet-induced obesity had been reversed by Roux-en-Y gastric bypass surgery.
resultsSHU9119 increased daily food intake (+ 100%), body weight (+30%), and fat mass (+50%) in rats with RYGB, surpassing the presurgical body weight and that of saline-treated sham-operated rats. Doubling of food intake was entirely due to increased meal frequency, but not meal size. After termination of SHU9119, body weight promptly returned to near preinfusion levels. In sham-operated rats, SHU9119 produced even larger increases in food intake and body weight.
conclusionsRYGB rats do not settle at a lower level of body weight because they cannot eat more food as they can easily double food intake by increasing meal frequency. The reversible obesity suggests that RYGB rats actively defend the lower body weight. However, because both RYGB and sham-operated rats responded to SHU9119, central melanocortin signaling is not the critical mechanism in RYGB rats responsible for this defense.
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