ReviewMicrobial drug resistance (Larchmont, N.Y.)2014
Peptidoglycan remodeling by the coordinated action of multispecific enzymes.
Review in Microbial drug resistance (Larchmont, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Identification and characterization of RacX, a new broad-specificity amino acid racemase from a novel taxon within the orderApplied and environmental microbiology · 2026Article
- O-Acetyl-L-homoserine sulfhydrylase from Thermotoga maritima has five enzyme activities.Extremophiles : life under extreme conditions · 2025Article
- Purification and characterization of a novel antibacterial peptide againstMicrobiology (Reading, England) · 2025Article
- Minimalist TetrazineJournal of the American Chemical Society · 2024Article
- Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Membrane vesicles inFrontiers in microbiology · 2023Article
- Article
- A NovelFrontiers in microbiology · 2021Article
- Analysis of Gram-negative Bacteria Peptidoglycan by Ultra-performance Liquid Chromatography.Bio-protocol · 2020Article
- Comparative transcriptomic analysis ofPeerJ · 2020Article
- L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking.ACS chemical biology · 2019Article
- The Staphylococcal Cell Wall.Microbiology spectrum · 2019Review
- Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis.Journal of biomolecular structure & dynamics · 2017Article
- Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody Recruitment.ACS infectious diseases · 2016Article
- D-Amino Acid Probes for Penicillin Binding Protein-based Bacterial Surface Labeling.The Journal of biological chemistry · 2015Article
- Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface.FEMS microbiology reviews · 2015Review
- The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11-12th March 2015).Frontiers in microbiology · 2015Article
- Bacterial d-amino acid oxidases: Recent findings and future perspectives.Bioengineered · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peptidoglycan (PG) cell wall constitutes the main defense barrier of bacteria against environmental insults and acts as communication interface. The biochemistry of this macromolecule has been well characterized throughout the years but recent discoveries have unveiled its chemical plasticity under environmental stresses. Non-canonical D-amino acids (NCDAA) are produced and released to the extracellular media by diverse bacteria. Such molecules govern cell wall adaptation to challenging environments through their incorporation into the polymer, a widespread capability among bacteria that reveals the inherent catalytic plasticity of the enzymes involved in the cell wall metabolism. Here, we analyze the recent structural and biochemical characterization of Bsr, a new family of broad spectrum racemases able to generate a wide range of NCDAA. We also discuss the necessity of a coordinated action of PG multispecific enzymes to generate adequate levels of modification in the murein sacculus. Finally, we also highlight how this catalytic plasticity of NCDAA-incorporating enzymes has allowed the development of new revolutionary methodologies for the study of PG modes of growth and in vivo dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.