Evidence map›Paper›PMID 24799153›Full record

Trial reportPain practice : the official journal of World Institute of Pain2015

Investigation of central nervous system dysfunction in chronic pelvic pain using magnetic resonance spectroscopy and noninvasive brain stimulation.

Marcel Simis, Jay S Reidler, Debora Duarte Macea, Ingrid Moreno Duarte, Xiaoen Wang, Robert Lenkinski, John C Petrozza, Felipe Fregni

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain practice : the official journal of World Institute of Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07303998 (Feasibility and Effect of Remotely Supervised Transcranial Direct Current Stimulation With Chair Yoga for Chronic Knee Pain Management in Older Adults With Alzheimer's Disease and Related Dementias.), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07303998 narecruitingnot on this mapstarted 2025, after this paper: background citation

Feasibility and Effect of Remotely Supervised Transcranial Direct Current Stimulation With Chair Yoga for Chronic Knee Pain Management in Older Adults With Alzheimer's Disease and Related Dementias.

TypeinterventionalSponsorUniversity of ArizonaRan2025 to 2026Enrolled40ConditionsAlzheimer&Amp, #39, s Disease, Other DementiasArmsActive tDCS paired with active online chair yoga
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  20. Neuromodulation for Chronic Pelvic Pain.Current urology reports · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marcel SimisLaboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, U.S.A.
Jay S ReidlerLaboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, U.S.A.
Debora Duarte MaceaLaboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, U.S.A.
Ingrid Moreno DuarteLaboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, U.S.A.
Xiaoen WangDepartment of Radiology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, U.S.A.
Robert LenkinskiDepartment of Radiology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, U.S.A.
John C PetrozzaDepartment of Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.
Felipe FregniLaboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, U.S.A.
Harvard University · USSpaulding Rehabilitation Hospital · USBeth Israel Deaconess Medical Center · US

Funding

Investigation and treatment of central nervous system dysfunction in chronic pelvR21DK081773 · NIDDK · SPAULDING REHABILITATION HOSPITAL · PI FREGNI, FELIPE · 2009 to 2010
$475k
NIDDK NIH HHS R21 7R21DK081773NIDDK NIH HHS R21 DK081773
6 · The paper itself

Abstract

backgroundRecent studies demonstrate that chronic pelvic pain is associated with altered afferent sensory input resulting in maladaptive changes in the neural circuitry of pain. To better understand the central changes associated with chronic pelvic pain, we investigated the contributions of critical pain-related neural circuits using single-voxel proton magnetic resonance spectroscopy (MRS) and transcranial direct current stimulation (tDCS).

methodsWe measured concentrations of neural metabolites in 4 regions of interest (thalamus, anterior cingulate cortex, primary motor, and occipital cortex [control]) at baseline and after 10 days of active or sham tDCS in patients with chronic pelvic pain. We then compared our results to those observed in healthy controls, matched by age and gender.

resultsWe observed a significant increase in pain thresholds after active tDCS compared with sham conditions. There was a correlation between metabolite concentrations at baseline and quantitative sensory assessments. Chronic pelvic pain patients had significantly lower levels of NAA/Cr in the primary motor cortex compared with healthy patients.

conclusionstDCS increases pain thresholds in patients with chronic pelvic pain. Biochemical changes in pain-related neural circuits are associated with pain levels as measured by objective pain testing. These findings support the further investigation of targeted cortical neuromodulatory interventions for chronic pelvic pain.

Indexed as

Motor CortexAdultChronic PainElectric Stimulation TherapyFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPain ManagementPain MeasurementPelvic PainTranscranial Direct Current Stimulationbrain stimulationchronic pelvic painmagnetic resonance spectroscopytDCStranscranial direct current stimulation

Identifiers

PMID24799153
PMCPMC4216781
OpenAlexW2119502400

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.