ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1989
Mineral catalysis of the formation of dimers of 5'-AMP in aqueous solution: the possible role of montmorillonite clays in the prebiotic synthesis of RNA.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- A quantitative model of enzyme-free copying of RNA with dimers.Nucleic acids research · 2025Article
- Spatial structure supports diversity in prebiotic autocatalytic chemical ecosystems.Npj complexity · 2025Article
- Mineral-Mediated Oligoribonucleotide Condensation: Broadening the Scope of Prebiotic Possibilities on the Early Earth.Life (Basel, Switzerland) · 2023Article
- Review
- Nonenzymatic polymerase-like template-directed synthesis of acyclic L-threoninol nucleic acid.Nature communications · 2021Article
- Greenalite Nanoparticles in Alkaline Vent Plumes as Templates for the Origin of Life.Astrobiology · 2021Article
- Continuous nonenzymatic cross-replication of DNA strands withChemical science · 2019Article
- Enzyme-free ligation of dimers and trimers to RNA primers.Nucleic acids research · 2019Article
- Enzyme-free genetic copying of DNA and RNA sequences.Beilstein journal of organic chemistry · 2018Review
- Walking over 4 Gya: Chemical Evolution from Photochemistry to Mineral and Organic Chemistries Leading to an RNA World.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Review
- Spontaneous Formation of RNA Strands, Peptidyl RNA, and Cofactors.Angewandte Chemie (International ed. in English) · 2015Article
- Adsorption of nucleic Acid bases, ribose, and phosphate by some clay minerals.Life (Basel, Switzerland) · 2015Review
- Formation of activated biomolecules by condensation on mineral surfaces--a comparison of peptide bond formation and phosphate condensation.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- Emergence of self-reproduction in cooperative chemical evolution of prebiological molecules.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Article
- Steps towards the formation of a protocell: the possible role of short peptides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
- Montmorillonite-catalysed formation of RNA oligomers: the possible role of catalysis in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
- Mineral induced formation of sugar phosphates.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1995Article
- The binding and reactions of nucleotides and polynucleotides on iron oxide hydroxide polymorphs.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1993Article
- Abiotic synthesis of amino acids under hydrothermal conditions and the origin of life: a perpetual phenomenon?Die Naturwissenschaften · 1992Article
- Oligomerization reactions of ribonucleotides: the reaction of the 5'-phosphorimidazolide of nucleosides on montmorillonite and other minerals.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reaction of the 5'-AMP with water soluble carbodiimide (EDAC) in the presence of Na+-montmorillonite 22A results in the formation of 2',5'-(pA)2 (18.9%), 3',5'-(pA)2 (11%), and AppA (4.8%). When poly(U) is used in place of the clay the product yields are 2',5'-(pA)2 (15.5%), 3',5'-(pA)2 (3.7%) and AppA (14.9%). The 3',5'-cyclic dinucleotide, 3',5'-c(pA)2, is also formed when poly(U) is used. AppA is the principal reaction product when neither clay nor poly(U) is present in the reaction mixture. Products which contain the phosphodiester bond are formed at different ionic strengths, pH and temperatures using Na+-montmorillonite. Phosphodiester bond formation was not observed when Cu2+-montmorillonite was used or when DISN was used in the place of EDAC. The extent catalysis of phosphodiester bond formation varied with the particular clay mineral used. Those Na+-clays which bind 5'-AMP more strongly are better catalysts. Cu2+-montmorillonite, which binds 5'-AMP strongly, exhibits no catalytic activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.