ArticleFunctional & integrative genomics2014
Influence of mosquito genotype on transcriptional response to dengue virus infection.
Article in Functional & integrative genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Susceptibility of diverse sand fly species to Toscana virus.PLoS neglected tropical diseases · 2025Article
- Determining dengue infection risk in the Colombo district of Sri Lanka by inferencing the genetic parameters of Aedes mosquitoes.BMC infectious diseases · 2024Article
- Controlling arbovirus infection: high-throughput transcriptome and proteome insights.Frontiers in microbiology · 2024Review
- Immune-related transcripts, microbiota and vector competence differ in dengue-2 virus-infected geographically distinct Aedes aegypti populations.Parasites & vectors · 2023Article
- Factors Affecting Arbovirus Midgut Escape in Mosquitoes.Pathogens (Basel, Switzerland) · 2023Review
- Intrinsic factors driving mosquito vector competence and viral evolution: a review.Frontiers in cellular and infection microbiology · 2023Review
- Transcriptome comparison of dengue-susceptible and -resistant field derived strains of Colombian Aedes aegypti using RNA-sequencing.Memorias do Instituto Oswaldo Cruz · 2021Article
- Homologs of Human Dengue-Resistance Genes,Insects · 2019Article
- Differential Effects of Temperature and Mosquito Genetics Determine Transmissibility of Arboviruses byThe American journal of tropical medicine and hygiene · 2018Article
- Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus.PLoS neglected tropical diseases · 2018Article
- Implications of autophagy on arbovirus infection of mosquitoes.Current opinion in insect science · 2017Review
- Genome Investigations of Vector Competence in Aedes aegypti to Inform Novel Arbovirus Disease Control Approaches.Insects · 2016Review
- Apoptosis-related genes control autophagy and influence DENV-2 infection in the mosquito vector, Aedes aegypti.Insect biochemistry and molecular biology · 2016Article
- Population genetics of the Asian tiger mosquito Aedes albopictus, an invasive vector of human diseases.Heredity · 2016Review
- Genomic approaches for understanding dengue: insights from the virus, vector, and host.Genome biology · 2016Review
- Dengue in Java, Indonesia: Relevance of Mosquito Indices as Risk Predictors.PLoS neglected tropical diseases · 2016Article
- Dissecting vectorial capacity for mosquito-borne viruses.Current opinion in virology · 2015Review
- Contrasting genetic structure between mitochondrial and nuclear markers in the dengue fever mosquito from Rio de Janeiro: implications for vector control.Evolutionary applications · 2015Article
- Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein.PLoS pathogens · 2015Article
- Identifying avian malaria vectors: sampling methods influence outcomes.Parasites & vectors · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The mosquito Aedes aegypti is the principal vector that transmits dengue virus (DENV) to humans. The primary factors that trigger a susceptible or refractory interaction of A. aegypti with DENV are not well understood. In this study, our aim is to characterize the influence of vector genotype on differential gene expression of susceptible vs. refractory A. aegypti strains to DENV infection. To accomplish that, we identified differential expression of a set of complementary DNAs (cDNAs; n = 9,504) of the D2S3 (susceptible) and Moyo-D (refractory) strains of A. aegypti to DENV serotype 2 (JAM1409) and compared these results to the differential expression of cDNAs in a different susceptible vector genotype (Moyo-S) relative to the same refractory genotype (Moyo-D) identified from our previous study. We observed that, although the number of differentially expressed transcripts (DETs) was similar in both the studies, about ~95% of the DETs were distinct between Moyo-D/D2S3 vs. Moyo-D/Moyo-S. This suggested that A. aegypti response, to infection of a given genotype of dengue, is largely dependent upon the vector genotype. However, we observed a set of common DETs among the vector strains that were associated with predicted functions such as endocytosis, regulation of autophagy, peroxisome, and lipid metabolism that may be relatively universal in conferring mosquito response to DENV infection.
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