ArticleThe Journal of cell biology2014
The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Effects ofExperimental and therapeutic medicine · 2026Article
- Article
- Klebsiella pneumoniae AI-2 transporters mediate interspecies interactions and composition in a three-species biofilm community.NPJ biofilms and microbiomes · 2024Article
- The Myosin-V Myo51 and Alpha-Actinin Ain1p Cooperate during Contractile Ring Assembly and Disassembly in Fission Yeast Cytokinesis.Journal of fungi (Basel, Switzerland) · 2024Article
- Acetylation of fission yeast tropomyosin does not promote differential association with cognate formins.Cytoskeleton (Hoboken, N.J.) · 2023Article
- Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.Molecular cell · 2022Article
- Simulated actin reorganization mediated by motor proteins.PLoS computational biology · 2022Article
- Microtubule-independent movement of the fission yeast nucleus.Journal of cell science · 2021Article
- Article
- ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway.Life science alliance · 2021Article
- Mechanism of membrane-curvature generation by ER-tubule shaping proteins.Nature communications · 2021Article
- Microtubule nucleation promoters Mto1 and Mto2 regulate cytokinesis in fission yeast.Molecular biology of the cell · 2020Article
- Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.Current biology : CB · 2019Article
- Molecular Mechanism of Cytokinesis.Annual review of biochemistry · 2019Review
- Actin turnover ensures uniform tension distribution during cytokinetic actomyosin ring contraction.Molecular biology of the cell · 2019Article
- The adaptor protein melanophilin regulates dynamic myosin-Va:cargo interaction and dendrite development in melanocytes.Molecular biology of the cell · 2019Article
- Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.Molecular biology of the cell · 2018Article
- Regulation of class V myosin.Cellular and molecular life sciences : CMLS · 2018Review
- Nine unanswered questions about cytokinesis.The Journal of cell biology · 2017Review
- Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis.The Journal of cell biology · 2017Article
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Authors and funding
7 authors.
Funding
Abstract
The myosin-V family of molecular motors is known to be under sophisticated regulation, but our knowledge of the roles and regulation of myosin-Vs in cytokinesis is limited. Here, we report that the myosin-V Myo51 affects contractile ring assembly and stability during fission yeast cytokinesis, and is regulated by two novel coiled-coil proteins, Rng8 and Rng9. Both rng8Δ and rng9Δ cells display similar defects as myo51Δ in cytokinesis. Rng8 and Rng9 are required for Myo51's localizations to cytoplasmic puncta, actin cables, and the contractile ring. Myo51 puncta contain multiple Myo51 molecules and walk continuously on actin filaments in rng8(+) cells, whereas Myo51 forms speckles containing only one dimer and does not move efficiently on actin tracks in rng8Δ. Consistently, Myo51 transports artificial cargos efficiently in vivo, and this activity is regulated by Rng8. Purified Rng8 and Rng9 form stable higher-order complexes. Collectively, we propose that Rng8 and Rng9 form oligomers and cluster multiple Myo51 dimers to regulate Myo51 localization and functions.
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