Evidence map›Paper›PMID 24798585›Full record

ArticleMolecular psychiatry2015

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia.

J Kuhn, K Hardenacke, D Lenartz, T Gruendler, M Ullsperger, C Bartsch, J K Mai, K Zilles, A Bauer, A Matusch and 12 more

4 registry-linked trialsOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 114 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 4 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03959124 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effect of Deep Brain Stimulation on Memory Network and Neurological Function of Alzheimer's Disease

TypeinterventionalSponsorBuddhist Tzu Chi General HospitalRan2020 to 2021Enrolled30ConditionsAlzheimer Disease, Dementia, Alzheimer Type, Deep Brain StimulationArmsDeep brain stimulation, Best medical treatment for Alzheimer's disease
NCT04571112 nacompletednot on this mapstarted 2017, after this paper: background citation

Multi-targets, Single-lead GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment

TypeinterventionalSponsorUniversity of TorontoRan2017 to 2021Enrolled6ConditionsParkinson Disease, Memory DisordersArmsNBM stimulation using the Vercise device (Boston Scientific, Marlborough, Massachusetts, US)
NCT05320523 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Simultaneous Deep Brain Stimulation of the Globus Pallidus Internus and the Nucleus Basalis of Meynert in Patients With Parkinson's Disease and Mild Cognitive Impairment

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2024Enrolled10ConditionsParkinson Disease, Mild Cognitive ImpairmentArmsDeep brain stimulation implantation of a Vercise neurostimulation system in GPi and NBM., GPi stimulation, NBM stimulation, Sham stimulation
NCT05882344 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Cholinergic Deep Brain Stimulation for Alzheimer's Disease

TypeinterventionalSponsorVanderbilt University Medical CenterRan2026 to 2028Enrolled2ConditionsAlzheimer Disease, Early Onset, Dementia, Alzheimer DiseaseArmsDevice Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 4 syntheses or guidelines pooled it, 264 citations in OpenAlex.

  1. An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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  20. Basal forebrain activation improves working memory in senescent monkeys.bioRxiv : the preprint server for biology · 2024
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 1 country.

J KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
K HardenackeDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
D LenartzDepartment of Functional Neurosurgery and Stereotaxy, University of Cologne, Cologne, Germany.
T Gruendler1] Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany [2] Faculty of Economics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany [3] Center for Behavioral Brain Sciences, Magdeburg, Germany.
M Ullsperger1] Center for Behavioral Brain Sciences, Magdeburg, Germany [2] Institute of Psychology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
C BartschDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
J K MaiDepartment of Neuroanatomy, University of Düsseldorf, Düsseldorf, Germany.
K Zilles1] Institute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany [2] University Hospital of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.
A Bauer1] Institute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany [2] Department of Neurology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
A MatuschInstitute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.
R-J SchulzUniversity of Cologne, Department of Geriatrics and St. Marien-Hospital, Cologne, Germany.
M NoreikUniversity of Cologne, Department of Geriatrics and St. Marien-Hospital, Cologne, Germany.
C P BührleDepartment of Functional Neurosurgery and Stereotaxy, University of Cologne, Cologne, Germany.
D MaintzUniversity of Cologne, Department for Radiology, Cologne, Germany.
C WoopenUniversity of Cologne, Research Unit Ethics, Institute for the History of Medicine and Medical Ethics, Cologne, Germany.
P HäussermannLVR Clinic Cologne, Department of Gerontopsychiatry, Cologne, Germany.
M HellmichUniversity of Cologne, Institute of Medical Statistics, Informatics and Epidemiology, Cologne, Germany.
J KlosterkötterDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
J WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Göttingen, Germany.
M MaaroufDepartment of Stereotaxy and Functional Neurosurgery, Klinikum Merheim, Cologne, Germany.
H-J FreundDepartment of Neuroanatomy, University of Düsseldorf, Düsseldorf, Germany.
V SturmDepartment of Functional Neurosurgery and Stereotaxy, University of Cologne, Cologne, Germany.
University of Cologne · DEHeinrich Heine University Düsseldorf · DEForschungszentrum Jülich · DEUniversity Hospital Cologne · DECenter for Behavioral Brain Sciences · DELungenklinik Köln-Merheim · DELVR-Klinik Köln · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholinergic neurons of the medial forebrain are considered important contributors to brain plasticity and neuromodulation. A reduction of cholinergic innervation can lead to pathophysiological changes of neurotransmission and is observed in Alzheimer's disease. Here we report on six patients with mild to moderate Alzheimer's disease (AD) treated with bilateral low-frequency deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM). During a four-week double-blind sham-controlled phase and a subsequent 11-month follow-up open label period, clinical outcome was assessed by neuropsychological examination using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome measure. Electroencephalography and [(18)F]-fluoro-desoxyglucose positron emission tomography were, besides others, secondary endpoints. On the basis of stable or improved primary outcome parameters twelve months after surgery, four of the six patients were considered responders. No severe or non-transitional side effects related to the stimulation were observed. Taking into account all limitations of a pilot study, we conclude that DBS of the NBM is both technically feasible and well tolerated.

Indexed as

Treatment OutcomeAgedAlzheimer DiseaseBasal Nucleus of MeynertDeep Brain StimulationElectroencephalographyFemaleFluorodeoxyglucose F18Follow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPsychiatric Status Rating ScalesFluorodeoxyglucose F18

Identifiers

PMID24798585
OpenAlexW2091447671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.