ArticleBioconjugate chemistry2014
Supramolecular assemblies of a conjugate of nucleobase, amino acids, and saccharide act as agonists for proliferation of embryonic stem cells and development of zygotes.
Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Review
- Biological functions of supramolecular assemblies of small molecules in cellular environment.RSC chemical biology · 2021Article
- A biocompatible supramolecular hydrogel with multivalent galactose ligands inhibitingRSC advances · 2020Article
- Dynamic Continuum of Molecular Assemblies for Controlling Cell Fates.Chembiochem : a European journal of chemical biology · 2019Article
- Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles.Chemical science · 2019Article
- Theoretical insights into aggregation-induced helicity modulation of a perylene bisimide derivative.Journal of molecular modeling · 2018Article
- Self-assembly of nucleopeptides to interact with DNAs.Interface focus · 2017Article
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Bioinspired assembly of small molecules in cell milieu.Chemical Society reviews · 2017Review
- Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents.Theranostics · 2017Article
- Design and Synthesis of Nanofibers of Self-assembledTetrahedron · 2016Article
- Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility.Nano letters · 2016Article
- Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells.Journal of the American Chemical Society · 2016Article
- Supramolecular biomaterials.Nature materials · 2016Review
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
- Nanoscale Assemblies of Small Molecules Control the Fate of Cells.Nano today · 2015Article
- Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.Cellular and molecular bioengineering · 2015Article
- Article
- Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide.Beilstein journal of organic chemistry · 2015Article
- De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo.Bioconjugate chemistry · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
The synthetic challenges in glycobiology and glycochemistry hamper the development of glycobiomaterials for biomedicine. Here we report the use of molecular self-assembly to sidestep the laborious synthesis of complex glycans for promoting the proliferation of murine embryonic stem (mES) cells. Our study shows that the supramolecular assemblies of a small molecule conjugate of nucleobase, amino acids, and saccharide, as a de novo glycoconjugate, promote the proliferation of mES cells and the development of zygotes into blastocysts of mouse. Molecular engineering confirms that each motif (i.e., adenine, Arg-Gly-Asp (RGD) domain, and glucosamine) is indispensable for the observed activity of the conjugate. As the first example of using assemblies of the molecular conjugates of multiple fundamental biological building blocks to control cell behaviors, this work illustrates an unprecedented approach to use supramolecular assemblies as multifunctional mimics of glycoconjugates.
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