Evidence map›Paper›PMID 24797834›Full record

ArticleBioconjugate chemistry2014

Monoalkoxy BODIPYs--a fluorophore class for bioimaging.

Alexandra M Courtis, Sofia A Santos, Yinghua Guan, J Adam Hendricks, Balaram Ghosh, D Miklos Szantai-Kis, Surya A Reis, Jagesh V Shah, Ralph Mazitschek

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. BODIPY Compounds Substituted on Boron.Molecules (Basel, Switzerland) · 2024
    Review
  3. Concerning the photophysics of fluorophores towards tailored bioimaging compounds: a case study involving S100A9 inflammation markers.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  4. Imaging of KChemMedChem · 2023
    Article
  5. Article
  6. BODIPY Fluorophores for Membrane Potential Imaging.Journal of the American Chemical Society · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Fluorescent vinblastine probes for live cell imaging.Chemical communications (Cambridge, England) · 2016
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra M CourtisCenter for Systems Biology and ∥Center for Human Genetic Research, Massachusetts General Hospital , 185 Cambridge Street, Boston, Massachusetts 02114, United States.
Sofia A Santos
Yinghua Guan
J Adam Hendricks
Balaram Ghosh
D Miklos Szantai-Kis
Surya A Reis
Jagesh V Shah
Ralph Mazitschek

Funding

StatisticsP50CA086355 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2015
$27.8M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
NCI NIH HHS P50 CA086355NCI NIH HHS P50CA086355NCI NIH HHS T32 CA079443NCI NIH HHS T32-CA079443
6 · The paper itself

Abstract

Small molecule fluorophores are indispensable tools for modern biomedical imaging techniques. In this report, we present the development of a new class of BODIPY dyes based on an alkoxy-fluoro-boron-dipyrromethene core. These novel fluorescent dyes, which we term MayaFluors, are characterized by good aqueous solubility and favorable in vitro physicochemical properties. MayaFluors are readily accessible in good yields in a one-pot, two-step approach starting from well-established BODIPY dyes, and allow for facile modification with functional groups of relevance to bioconjugate chemistry and bioorthogonal labeling. Biological profiling in living cells demonstrates excellent membrane permeability, low nonspecific binding, and lack of cytotoxicity.

Indexed as

Boron CompoundsCell Membrane PermeabilityCell SurvivalFemaleFluorescent DyesHumansMCF-7 CellsMolecular ImagingMolecular StructureSolubilityTumor Cells, Cultured4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent Dyes

Identifiers

PMID24797834
PMCPMC4215867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.