ArticleJournal of clinical laboratory analysis2015
Can Procalcitonin in Cerebrospinal Fluid be a Diagnostic Tool for Meningitis?
Article in Journal of clinical laboratory analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03387969 (Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- The Diagnostic Utility of Cerebrospinal Fluid Procalcitonin for Acute Bacterial Meningitis and Ventriculitis in Children: A Multicenter Prospective Study.Acta medica Philippina · 2025Article
- Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections.The Journal of infection · 2024Article
- Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.PloS one · 2021Article
- A 2020 review on the role of procalcitonin in different clinical settings: an update conducted with the tools of the Evidence Based Laboratory Medicine.Annals of translational medicine · 2020Review
- Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department.Yeungnam University journal of medicine · 2020Article
- C - reactive protein of cerebrospinal fluid, as a sensitive approach for diagnosis of neonatal meningitis.African health sciences · 2019Article
- Usefulness of the procalcitonin test in young febrile infants between 1 and 3 months of age.Korean journal of pediatrics · 2018Article
- The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review.Journal of clinical medicine · 2018Review
- Correlation between CD64 and PCT levels in cerebrospinal fluid and degree of hearing impairment sequelae in neonates with purulent meningitis.Experimental and therapeutic medicine · 2017Article
- Development and Validation of an Ultrasensitive Procalcitonin Sandwich Immunoassay.High-throughput · 2017Article
- Cerebrospinal fluid procalcitonin as a biomarker of bacterial meningitis in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Procalcitonin in cerebrospinal fluid in meningitis: a prospective diagnostic study.Brain and behavior · 2016Article
- Clinical decision rules for acute bacterial meningitis: current insights.Open access emergency medicine : OAEM · 2016Review
- Spectrum of complicated migraine in children: A common profile in aid to clinical diagnosis.World journal of clinical pediatrics · 2015Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo study the levels of procalcitonin (PCT) in patients with meningitis and control group and compare them with established markers of infection--such as C-reactive protein (CRP), high-sensitivity CRP, and WBC--in cerebrospinal fluid (CSF) and assess the possible discriminative role of PCT in the differential diagnosis of meningitis from other noninfectious diseases.
methodsWe studied CSF samples of patients from Intensive Care Unit, Internal Medicine, Neurology, Hematology, and Pediatric departments. The total number of patients included in the study was 58. The samples were divided into three groups: group 1 with bacterial meningitis (BM) central nervous system (n = 19); group 2 with viral meningitis (VM, n = 11); and group 3, control group, with noninfectious diseases (n = 28).
resultsValues of PCT levels >0.5 ng/ml were considered as abnormal. In group 1, mean PCT levels were 4.714 ± 1.59 ng/ml. In group 2, all patients had PCT <0.5 ng/ml (0.1327 ± 0.03 ng/ml). In group 3, the mean PCT levels were <0.1 ng/ml.
conclusionPCT values in CSF can be very helpful in distinguishing BM from VM and other noninfectious diseases.
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