Evidence map›Paper›PMID 24797659›Full record

Trial reportPsychophysiology2014

An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children.

David J Schaeffer, Cynthia E Krafft, Nicolette F Schwarz, Lingxi Chi, Amanda L Rodrigue, Jordan E Pierce, Jerry D Allison, Nathan E Yanasak, Tianming Liu, Catherine L Davis and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02227095 (Exercise & Overweight Children's Cognition), which is not on this map. Cited by 60 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02227095 nacompletednot on this map

Exercise & Overweight Children's Cognition

TypeinterventionalSponsorAugusta UniversityRan2008 to 2014Enrolled175ConditionsOverweight and ObesityArmsExercise, After-school program
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  16. Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David J SchaefferDepartment of Neuroscience, University of Georgia, Athens, Georgia, USA.
Cynthia E Krafft
Nicolette F Schwarz
Lingxi Chi
Amanda L Rodrigue
Jordan E Pierce
Jerry D Allison
Nathan E Yanasak
Tianming Liu
Catherine L Davis
Jennifer E McDowell

Funding

Exercise & Overweight Children's CognitionR01HL087923 · NHLBI · AUGUSTA UNIVERSITY · PI DAVIS, CATHERINE LUCY, MCDOWELL, JENNIFER E · 2008 to 2012
$5.2M
NHLBI NIH HHS R01 HL087923NHLBI NIH HHS R01 HL87923
6 · The paper itself

Abstract

In childhood, excess adiposity and low fitness are linked to poor academic performance, lower cognitive function, and differences in brain structure. Identifying ways to mitigate obesity-related alterations is of current clinical importance. This study examined the effects of an 8-month exercise intervention on the uncinate fasciculus, a white matter fiber tract connecting frontal and temporal lobes. Participants consisted of 18 unfit, overweight 8- to 11-year-old children (94% Black) who were randomly assigned to either an aerobic exercise (n = 10) or a sedentary control group (n = 8). Before and after the intervention, all subjects participated in a diffusion tensor MRI scan. Tractography was conducted to isolate the uncinate fasciculus. The exercise group showed improved white matter integrity as compared to the control group. These findings are consistent with an emerging literature suggesting beneficial effects of exercise on white matter integrity.

Indexed as

Exercise TherapyChildDiffusion Tensor ImagingFemaleFrontal LobeHumansMaleOverweightTemporal LobeTreatment OutcomeWhite MatterChildrenDiffusion tensor imagingExerciseObesityUncinate fasciculus

Identifiers

PMID24797659
PMCPMC4107135

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.