ArticlePloS one2014
Genomic responses to arsenic in the cyanobacterium Synechocystis sp. PCC 6803.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of Time Interval on Arsenic Toxicity to Paddy Field Cyanobacteria as Evident by Nitrogen Metabolism, Biochemical Constituent, and Exopolysaccharide Content.Biological trace element research · 2021Article
- Arsenate-Induced Changes in Bacterial Metabolite and Lipid Pools during Phosphate Stress.Applied and environmental microbiology · 2021Article
- New insights into toxic effects of arsenate on four Microcystis species under different phosphorus regimes.Environmental science and pollution research international · 2020Article
- Review
- Identification of Steps in the Pathway of Arsenosugar Biosynthesis.Environmental science & technology · 2019Article
- Identification of Resistance Genes and Response to Arsenic inFrontiers in microbiology · 2019Article
- Arsenic and high affinity phosphate uptake gene distribution in shallow submarine hydrothermal sediments.Biogeochemistry · 2018Article
- Contrasting the Genetic Patterns of Microbial Communities in Soda Lakes with and without Cyanobacterial Bloom.Frontiers in microbiology · 2018Article
- Co-expression of Cyanobacterial Genes for Arsenic Methylation and Demethylation inFrontiers in microbiology · 2017Article
- Photosynthetic Versatility in the Genome ofFrontiers in microbiology · 2016Article
- Probing Synechocystis-Arsenic Interactions through Extracellular Nanowires.Frontiers in microbiology · 2016Article
- Genomic analysis of parallel-evolved cyanobacterium Synechocystis sp. PCC 6803 under acid stress.Photosynthesis research · 2015Article
- Responses to oxidative and heavy metal stresses in cyanobacteria: recent advances.International journal of molecular sciences · 2014Review
- Metals in cyanobacteria: analysis of the copper, nickel, cobalt and arsenic homeostasis mechanisms.Life (Basel, Switzerland) · 2014Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arsenic is a ubiquitous contaminant and a toxic metalloid which presents two main redox states in nature: arsenite [As(III)] and arsenate [As(V)]. Arsenic resistance in Synechocystis sp. strain PCC 6803 is mediated by the arsBHC operon and two additional arsenate reductases encoded by the arsI1 and arsI2 genes. Here we describe the genome-wide responses to the presence of arsenate and arsenite in wild type and mutants in the arsenic resistance system. Both forms of arsenic produced similar responses in the wild type strain, including induction of several stress related genes and repression of energy generation processes. These responses were transient in the wild type strain but maintained in time in an arsB mutant strain, which lacks the arsenite transporter. In contrast, the responses observed in a strain lacking all arsenate reductases were somewhat different and included lower induction of genes involved in metal homeostasis and Fe-S cluster biogenesis, suggesting that these two processes are targeted by arsenite in the wild type strain. Finally, analysis of the arsR mutant strain revealed that ArsR seems to only control 5 genes in the genome. Furthermore, the arsR mutant strain exhibited hypersentivity to nickel, copper and cadmium and this phenotype was suppressed by mutation in arsB but not in arsC gene suggesting that overexpression of arsB is detrimental in the presence of these metals in the media.
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