Evidence map›Paper›PMID 24797238›Full record

SynthesisPloS one2014

A comparison of the analgesia efficacy and side effects of paravertebral compared with epidural blockade for thoracotomy: an updated meta-analysis.

Xibing Ding, Shuqing Jin, Xiaoyin Niu, Hao Ren, Shukun Fu, Quan Li

3 registry-linked trialsOpen access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02619513 phase4completednot on this map

Effects of Dexmedetomidine as an Adjunctive Analgesic Used in Continuous Thoracic Paravertebral Blocks for Post-thoracotomy Pain Syndrome

TypeinterventionalSponsorWeifeng TuRan2014 to 2015Enrolled60ConditionsPost-thoracotomy Pain SyndromeArmsDexmedetomidine, Ropivacaine, Mindray M7 series
NCT02909322 phase4unknown statusnot on this mapstarted 2016, after this paper: background citation

Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients

TypeinterventionalSponsorDr. Anthony HoRan2016 to 2023Enrolled50ConditionsPain Control After Elective HepatectomyArmsBupivacaine and Hydromorphone, Ropivacaine and Hydromorphone
NCT05812521 nacompletednot on this mapstarted 2020, after this paper: background citation

Efficacy of Thoracic Paravertebral Block With Methylene Blue Visual Confirmation in the Management of Postoperative Pain After Video-assisted Thoracoscopic Lobectomy

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2020 to 2022Enrolled120ConditionsPost Operative Pain, Thoracic CancerArmsParavertebral block with methylene blue, Thoracic Epidural Anesthesia
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xibing DingDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Shuqing JinDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Xiaoyin NiuDepartment of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Hao RenDepartment of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Shukun FuDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Quan LiDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe most recent systematic review and meta-analysis comparing the analgesic efficacy and side effects of paravertebral and epidural blockade for thoracotomy was published in 2006. Nine well-designed randomized trials with controversial results have been published since then. The present report constitutes an updated meta-analysis of this issue. SUMMARY OF

backgroundThoracotomy is a major surgical procedure and is associated with severe postoperative pain. Epidural analgesia is the gold standard for post-thoracotomy pain management, but has its limitations and contraindications, and paravertebral blockade is increasingly popular. However, it has not been decided whether the analgesic effect of the two methods is comparable, or whether paravertebral blockade leads to a lower incidence of adverse side effects after thoracotomy.

methodsTwo reviewers independently searched the databases PubMed, EMBASE, and the Cochrane Library (last performed on 1 February, 2013) for reports of studies comparing post-thoracotomy epidural analgesia and paravertebral blockade. The same individuals independently extracted data from the appropriate studies.

resultEighteen trials involving 777 patients were included in the current analysis. There was no significant difference in pain scores between paravertebral blockade and epidural analgesia at 4-8, 24, 48 hours, and the rates of pulmonary complications and morphine usage during the first 24 hours were also similar. However, paravertebral blockade was better than epidural analgesia in reducing the incidence of urinary retention (p<0.0001), nausea and vomiting (p = 0.01), hypotension (p<0.00001), and rates of failed block were lower in the paravertebral blockade group (p = 0.01).

conclusionsThis meta-analysis showed that PVB can provide comparable pain relief to traditional EPI, and may have a better side-effect profile for pain relief after thoracic surgery. Further high-powered randomized trials are to need to determine whether PVB truly offers any advantages over EPI.

Indexed as

ThoracostomyAnalgesia, EpiduralFemaleHumansMaleNauseaPain ManagementPain MeasurementPostoperative PainRandomized Controlled Trials as TopicUrinary RetentionVomiting

Identifiers

PMID24797238
PMCPMC4010440
OpenAlexW2041767976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.