ArticleThe Journal of antimicrobial chemotherapy2014
Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment.
Article in The Journal of antimicrobial chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 206 citations in OpenAlex.
- Antimicrobial resistance, conjugative plasmids and pathogenicity in wastewater and freshwater Escherichia spp. in Stockholm, Sweden.npj antimicrobials and resistance · 2026Article
- An Overview of the Presence of Cephalosporin Antibiotics in Aquatic Environments.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Identification and characterization ofJournal of water and health · 2026Article
- Stakeholder views on the implementation of the UK's Antimicrobial Resistance (AMR) National Action Plan (2019-2024) in relation to AMR in the environment.Global health action · 2025Article
- Molecular characterization of extended spectrum beta lactamase producing Escherichia coli in two different wastewater treatment plants in Hatay Province, Türkiye.Scientific reports · 2025Article
- Population Ecology-Quantitative Microbial Risk Assessment (QMRA) Model for Antibiotic-Resistant and SusceptibleEnvironmental science & technology · 2025Article
- Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.Antimicrobial resistance and infection control · 2024Article
- The Impact of Urban Pollution on Plasmid-Mediated Resistance Acquisition in Enterobacteria from a Tropical River.Antibiotics (Basel, Switzerland) · 2024Article
- Article
- Metagenomic insights into the wastewater resistome before and after purification at large‑scale wastewater treatment plants in the Moscow city.Scientific reports · 2024Article
- Isolation and Characterization of Environmental Extended Spectrum β-Lactamase-ProducingPharmaceuticals (Basel, Switzerland) · 2024Article
- Antibiotic Resistance Profile ofInternational journal of microbiology · 2024Article
- Surface water in Lower Saxony: A reservoir for multidrug-resistantOne health (Amsterdam, Netherlands) · 2023Article
- Characterization of Third Generation Cephalosporin- and Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Surveillance on ESBL-Antibiotics (Basel, Switzerland) · 2023Article
- The Phenomenon of Antibiotic Resistance in the Polar Regions: An Overview of the Global Problem.Infection and drug resistance · 2023Review
- Hospital and community wastewater as a source of multidrug-resistant ESBL-producingFrontiers in cellular and infection microbiology · 2023Article
- Comparison of HorizontalArchives of molecular biology and genetics · 2023Article
- Wastewater treatment plants, an "escape gate" for ESCAPE pathogens.Frontiers in microbiology · 2023Review
- Functional metagenomic libraries generated from anthropogenically impacted environments reveal importance of metabolic genes in biocide and antibiotic resistance.Current research in microbial sciences · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesMultidrug-resistant Enterobacteriaceae pose a significant threat to public health. We aimed to study the impact of sewage treatment effluent on antibiotic resistance reservoirs in a river.
methodsRiver sediment samples were taken from downstream and upstream of a waste water treatment plant (WWTP) in 2009 and 2011. Third-generation cephalosporin (3GC)-resistant Enterobacteriaceae were enumerated. PCR-based techniques were used to elucidate mechanisms of resistance, with a new two-step PCR-based assay developed to investigate bla(CTX-M-15) mobilization. Conjugation experiments and incompatibility replicon typing were used to investigate plasmid ecology.
resultsWe report the first examples of bla(CTX-M-15) in UK river sediment; the prevalence of bla(CTX-M-15) was dramatically increased downstream of the WWTP. Ten novel genetic contexts for this gene were identified, carried in pathogens such as Escherichia coli ST131 as well as indigenous aquatic bacteria such as Aeromonas media. The bla(CTX-M-15) -gene was readily transferable to other Gram-negative bacteria. We also report the first finding of an imipenem-resistant E. coli in a UK river.
conclusionsThe high diversity and host range of novel genetic contexts proves that evolution of novel combinations of resistance genes is occurring at high frequency and has to date been significantly underestimated. We have identified a worrying reservoir of highly resistant enteric bacteria in the environment that poses a threat to human and animal health.
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