ArticleNature communications2014
Controlled multistep synthesis in a three-phase droplet reactor.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.Lab on a chip · 2026Article
- Thermally Regulated Droplet Microfluidics Enables Uniform, Size-Controllable DNA-Nanoparticle Superlattices.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- High-Efficiency Continuous Microreactors for Controlled Synthesis of Nanosized Particles of Functional Materials: Review.Nanomaterials (Basel, Switzerland) · 2026Review
- An acoustofluidic embedding platform for rapid multiphase microparticle injection.Nature communications · 2025Article
- Wetting-induced interfacial instability: A mechanism for droplet emission at air-liquid interfaces.Science advances · 2025Article
- Dielectrophoretic bead-droplet reactor for solid-phase synthesis.Nature communications · 2024Article
- Review
- Evaluation of Analyte Transfer between Microfluidic Droplets by Mass Spectrometry.Analytical chemistry · 2023Article
- Continuous Electroformation of Gold Nanoparticles in Nanoliter Droplet Reactors.Angewandte Chemie (International ed. in English) · 2023Article
- Self-synchronization of reinjected droplets for high-efficiency droplet pairing and merging.Microsystems & nanoengineering · 2023Article
- Scalable Advanced Li(NiACS omega · 2022Article
- Automated and Dynamic Control of Chemical Content in Droplets for Scalable Screens of Small Animals.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Droplet Microfluidics and Directed Evolution of Enzymes: An Intertwined Journey.Angewandte Chemie (International ed. in English) · 2021Review
- A Magnetically Actuated Superhydrophobic Ratchet Surface for Droplet Manipulation.Micromachines · 2021Article
- Microdroplet Operations in Polymeric Microtubes.Analytical chemistry · 2021Article
- Mixing characterization of binary-coalesced droplets in microchannels using deep neural network.Biomicrofluidics · 2020Article
- Dynamics and controllability of droplet fusion under gas-liquid-liquid three-phase flow in a microfluidic reactor.RSC advances · 2020Article
- Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications.Molecules (Basel, Switzerland) · 2020Review
- Droplet Microfluidics-Enabled High-Throughput Screening for Protein Engineering.Micromachines · 2019Review
- Microfluidic assisted synthesis of PLGA drug delivery systems.RSC advances · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Channel-fouling is a pervasive problem in continuous flow chemistry, causing poor product control and reactor failure. Droplet chemistry, in which the reaction mixture flows as discrete droplets inside an immiscible carrier liquid, prevents fouling by isolating the reaction from the channel walls. Unfortunately, the difficulty of controllably adding new reagents to an existing droplet stream has largely restricted droplet chemistry to simple reactions in which all reagents are supplied at the time of droplet formation. Here we describe an effective method for repeatedly adding controlled quantities of reagents to droplets. The reagents are injected into a multiphase fluid stream, comprising the carrier liquid, droplets of the reaction mixture and an inert gas that maintains a uniform droplet spacing and suppresses new droplet formation. The method, which is suited to many multistep reactions, is applied to a five-stage quantum dot synthesis wherein particle growth is sustained by repeatedly adding fresh feedstock.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.