ArticleThe Journal of comparative neurology2014
Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Multiparametric Classification of Pure-tone Responses Distinguishes Neurons in Inferior Colliculus Subdivisions.bioRxiv : the preprint server for biology · 2026Article
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Segregated input to thalamic areas that project differently to core and shell auditory cortical fields.iScience · 2025Article
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Recurrent Circuits Amplify Corticofugal Signals and Drive Feedforward Inhibition in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Embryonic medial ganglionic eminence cells survive and integrate into the inferior colliculus of adult mice.Hearing research · 2022Article
- Long-Duration Sound-Induced Facilitation Changes Population Activity in the Inferior Colliculus.Frontiers in systems neuroscience · 2022Article
- Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus.Frontiers in neural circuits · 2021Article
- Subtypes of GABAergic cells in the inferior colliculus.Hearing research · 2019Review
- A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice.eLife · 2019Article
- Organization of projection from brainstem auditory nuclei to the inferior colliculus of Japanese house bat (Pipistrellus abramus).Brain and behavior · 2018Article
- Neuronal Organization in the Inferior Colliculus Revisited with Cell-Type-Dependent Monosynaptic Tracing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inhibitory Neural Circuits in the Mammalian Auditory Midbrain.Journal of experimental neuroscience · 2018Review
- Identified GABAergic and Glutamatergic Neurons in the Mouse Inferior Colliculus Share Similar Response Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Synchrony, connectivity, and functional similarity in auditory midbrain local circuits.Neuroscience · 2016Article
- Extracellular Molecular Markers and Soma Size of Inhibitory Neurons: Evidence for Four Subtypes of GABAergic Cells in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Long-Lasting Sound-Evoked Afterdischarge in the Auditory Midbrain.Scientific reports · 2016Article
- Functional organization of the local circuit in the inferior colliculus.Anatomical science international · 2016Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Large GABAergic (LG) neurons are a distinct type of neuron in the inferior colliculus (IC) identified by their dense vesicular glutamate transporter 2 (VGLUT2)-containing axosomatic synaptic terminals. Yet the sources of these terminals are unknown. Since IC glutamatergic neurons express VGLUT2, and IC neurons are known to have local collaterals, we tested the hypothesis that these excitatory, glutamatergic axosomatic inputs on LG neurons come from local axonal collaterals and commissural IC neurons. We injected a recombinant viral tracer into the IC which enabled Golgi-like green fluorescent protein (GFP) labeling in both dendrites and axons. In all cases, we found terminals positive for both GFP and VGLUT2 (GFP+/VGLUT2+) that made axosomatic contacts on LG neurons. One to six axosomatic contacts were made on a single LG cell body by a single axonal branch. The GFP-labeled neurons giving rise to the VGLUT2+ terminals on LG neurons were close by. The density of GFP+/VGLUT2+ terminals on the LG neurons was related to the number of nearby GFP-labeled cells. On the contralateral side, a smaller number of LG neurons received axosomatic contacts from GFP+/VGLUT2+ terminals. In cases with a single GFP-labeled glutamatergic neuron, the labeled axonal plexus was flat, oriented in parallel to the fibrodendritic laminae, and contacted 9-30 LG cell bodies within the plexus. Our data demonstrated that within the IC microcircuitry there is a convergence of inputs from local IC excitatory neurons on LG cell bodies. This suggests that LG neurons are heavily influenced by the activity of the nearby laminar glutamatergic neurons in the IC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.