ReviewBrain connectivity2014
Network dysfunction in Alzheimer's disease: refining the disconnection hypothesis.
Review in Brain connectivity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 2 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Does Functional Connectivity Provide a Marker for Cognitive Rehabilitation Effects in Alzheimer's Disease? An Interventional Study.Journal of Alzheimer's disease : JAD · 2017Trial
- Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI.PloS one · 2015Trial
- Neuromodulation techniques targeting neurotransmitter dysfunction: Innovation in treatments for Alzheimer's disease.Neural regeneration research · 2026Article
- Bayesian brain edge-based connectivity (BBeC): a Bayesian model for brain edge-based connectivity inference.BMC bioinformatics · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects.iScience · 2026Article
- Linking EEG markers of oscillopathy and default mode network dysfunction in Alzheimer's disease.Frontiers in human neuroscience · 2026Review
- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.Frontiers in aging neuroscience · 2026Article
- Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory.Human brain mapping · 2025Article
- Alterations of the brain functional organization in young-onset Alzheimer's disease: Is it a matter of "time"?Journal of Alzheimer's disease : JAD · 2025Article
- Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2025Article
- Multivariate whole brain neurodegenerative-cognitive-clinical severity mapping in the Alzheimer's disease continuum using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Molecular psychiatry · 2025Article
- Revealing excitation-inhibition imbalance in Alzheimer's disease using multiscale neural model inversion of resting-state functional MRI.Communications medicine · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Much effort in recent years has focused on understanding the effects of Alzheimer's disease (AD) on neural function. This effort has resulted in an enormous number of papers describing different facets of the functional derangement seen in AD. A particularly important tool for these investigations has been resting-state functional connectivity. Attempts to comprehensively synthesize resting-state functional connectivity results have focused on the potential utility of functional connectivity as a biomarker for disease risk, disease staging, or prognosis. While these are all appropriate uses of this technique, the purpose of this review is to examine how functional connectivity disruptions inform our understanding of AD pathophysiology. Here, we examine the rationale and methodological considerations behind functional connectivity studies and then provide a critical review of the existing literature. In conclusion, we propose a hypothesis regarding the development and spread of functional connectivity deficits seen in AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.