Trial reportFertility and sterility2014
A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T).
Trial report in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00246506 (Optimal Infertility Therapy RCT), which is not on this map. Cited by 50 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimal Infertility Therapy RCT: Women 40 and Older
Who cites it
50 citing papers in PubMed, 8 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis.Human reproduction update · 2024Pooled it
- In vitro fertilisation for unexplained subfertility.The Cochrane database of systematic reviews · 2023Pooled it
- Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis.Human reproduction update · 2022Pooled it
- Ovulation induction and intrauterine insemination in women of advanced reproductive age: a systematic review of the literature.Journal of assisted reproduction and genetics · 2022Pooled it
- Intrauterine insemination + controlled ovarian hyperstimulation versus in vitro fertilisation in unexplained infertility: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2022Pooled it
- Interventions for unexplained infertility: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2019Pooled it
- Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation.The Cochrane database of systematic reviews · 2017Pooled it
- In vitro fertilisation for unexplained subfertility.The Cochrane database of systematic reviews · 2015Pooled it
- Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation.BMJ (Clinical research ed.) · 2015Trial
- When is clomiphene or gonadotropin intrauterine insemination futile? Results of the Fast Track and Standard Treatment Trial and the Forty and Over Treatment Trial, two prospective randomized controlled trials.Fertility and sterility · 2014Trial
- Trends in infertility treatments by race, ethnicity, socioeconomic status, and region in US birth certificates from live births: 2011 to 2022.American journal of obstetrics and gynecology · 2026Article
- Correlation between novel hematological parameters and assisted pregnancy outcome in frozen-thawed embryo transfer patients.Frontiers in cell and developmental biology · 2026Article
- Ovarian aging: a missing diagnosis in reproductive medicine.Nature medicine · 2025Article
- The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up.Journal of clinical medicine · 2024Article
- Role of In Vitro Fertilization (IVF) in Unexplained Infertility Management: A Systematic Review.Cureus · 2024Review
- Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care.Medicina (Kaunas, Lithuania) · 2023Article
- Should IUI replace IVF as first-line treatment for unexplained infertility? A literature review.BMC women's health · 2023Review
- Optimizing pregnancy outcomes in intrauterine insemination cycles by stratifying pre-wash total motile count and patient-specific factors: a patient counseling tool.Journal of assisted reproduction and genetics · 2022Article
- A SART data cost-effectiveness analysis of planned oocyte cryopreservation versus in vitro fertilization with preimplantation genetic testing for aneuploidy considering ideal family size.Fertility and sterility · 2022Article
- The COVID-19 Vaccine Opinions of Women Planning a Pregnancy: International Web Blogs Scanning.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo determine the optimal infertility therapy for women at the end of their reproductive potential.
designRandomized clinical trial.
settingAcademic medical centers and private infertility center in a state with mandated insurance coverage. PATIENT(S): Couples with ≥ 6 months of unexplained infertility; female partner aged 38-42 years. INTERVENTION(S): Randomized to treatment with two cycles of clomiphene citrate (CC) and intrauterine insemination (IUI), follicle stimulating hormone (FSH)/IUI, or immediate IVF, followed by IVF if not pregnant. MAIN OUTCOME MEASURE(S): Proportion with a clinically recognized pregnancy, number of treatment cycles, and time to conception after two treatment cycles and at the end of treatment. RESULT(S): We randomized 154 couples to receive CC/IUI (N = 51), FSH/IUI (N = 52), or immediate IVF (N = 51); 140 (90.9%) couples initiated treatment. The cumulative clinical pregnancy rates per couple after the first two cycles of CC/IUI, FSH/IUI, or immediate IVF were 21.6%, 17.3%, and 49.0%, respectively. After all treatments, 110 (71.4%) of 154 couples had conceived a clinically recognized pregnancy, and 46.1% had delivered at least one live-born baby; 84.2% of all live-born infants resulting from treatment were achieved via IVF. There were 36% fewer treatment cycles in the IVF arm compared with either COH/IUI arm, and the couples conceived a pregnancy leading to a live birth after fewer treatment cycles. CONCLUSION(S): A randomized controlled trial in older women with unexplained infertility to compare treatment initiated with two cycles of controlled ovarian hyperstimulation/IUI versus immediate IVF demonstrated superior pregnancy rates with fewer treatment cycles in the immediate IVF group. CLINICAL TRIAL REGISTRATION NUMBER: NCT00246506.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.