ArticleClinical endocrinology2014
X chromosome parental origin and aortic stiffness in turner syndrome.
Article in Clinical endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- A Review of Recent Developments in Turner Syndrome Research.Journal of cardiovascular development and disease · 2021Review
- Mosaic Turner syndrome shows reduced penetrance in an adult population study.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Cardiometabolic health in Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Proceedings from the Turner Resource Network symposium: the crossroads of health care research and health care delivery.American journal of medical genetics. Part A · 2015Article
- Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome.Journal of cardiovascular development and disease · 2015Article
- The relation between X chromosome parental origin and aortic stiffness in patients with Turner's syndrome: role of hypertension and antihypertensive drugs.Clinical endocrinology · 2015Article
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7 authors at 4 institutions in 1 country.
Funding
Abstract
introductionAortic abnormalities contribute to increased morbidity and mortality of women with Turner syndrome (TS). Impaired aortic stiffness may prove to have clinical prognostic value in TS as is the case in other diseases such as Marfan syndrome, diabetes and hypertension. Additionally, the parental origin of the X chromosome in TS may influence aortic stiffness.
objectiveTo assess the relation between X chromosome parental origin and aortic stiffness in TS patients.
methodsTwenty-four subjects with TS participated in this cross-sectional study at a tertiary care centre. The parental origin of the X chromosome was determined. Cardiac-gated multidetector computerized tomography (MDCT) was performed and distensibility of the ascending aorta (AA), a measure of aortic stiffness, was calculated.
resultsFourteen women were Xm (maternal origin) and 10 were Xp (paternal origin) for their inheritance of the single X chromosome. Age, body size, blood pressure and AA areas were similar in the two groups. However, the calculated AA distensibility was significantly lower in the Xm group (2·8 ± 1·1 mm/Hg) than in the Xp group (4·1 ± 1·5 mm/Hg); P < 0·05. Conclusion This study demonstrates that TS subjects that inherit their single X chromosome from their mother (Xm) have a significantly stiffer aorta compared with the TS with a paternally originating X chromosome (Xp), consistent with a potentially greater risk for cardiovascular complications. These findings suggest that parental chromosomal analysis and aortic stiffness measurements would be useful for the risk assessment and clinical management of TS patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.