ArticleActa neurologica Scandinavica2014
Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy.
Article in Acta neurologica Scandinavica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis.NeuroImage. Clinical · 2016Pooled it
- Increased volumes of the precuneus and the pallidum in idiopathic generalized epilepsy.Scientific reports · 2025Article
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- A correlational study between microstructural, macrostructural and functional age-related changes in the human visual cortex.PloS one · 2023Article
- Identifying epilepsy based on machine-learning technique with diffusion kurtosis tensor.CNS neuroscience & therapeutics · 2022Article
- Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2022Article
- Fiber ball white matter modeling in focal epilepsy.Human brain mapping · 2021Article
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy.Frontiers in neurology · 2021Article
- White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study.Brain : a journal of neurology · 2020Article
- Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic-clonic seizures.Experimental and therapeutic medicine · 2019Article
- Diffusion Kurtosis as an in vivo Imaging Marker of Early Radiation-Induced Changes in Radiation-Induced Temporal Lobe Necrosis in Nasopharyngeal Carcinoma Patients.Clinical neuroradiology · 2018Article
- Effects of SYN1Human brain mapping · 2018Article
- Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic-clonic seizure.Human brain mapping · 2016Article
- Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy.Epilepsia · 2016Article
- The potential role of novel diffusion imaging techniques in the understanding and treatment of epilepsy.Quantitative imaging in medicine and surgery · 2015Review
- What does diffusion tensor imaging (DTI) tell us about cognitive networks in temporal lobe epilepsy?Quantitative imaging in medicine and surgery · 2015Review
- Kurtosis analysis of neural diffusion organization.NeuroImage · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesIdiopathic generalized epilepsy (IGE) arises from paroxysmal dysfunctions of the thalamo-cortical network. One of the hallmarks of IGE is the absence of visible abnormalities on routine magnetic resonance imaging (MRI). However, recent quantitative MRI studies showed cortical-subcortical structural abnormalities in IGE, but the extent of abnormalities has been inconsistent in the literature. The inconsistencies may be associated with complex microstructural abnormalities in IGE that are not completely detectable using conventional diffusion tensor imaging methods. The goal of this study was to investigate white-matter (WM) microstructural abnormalities in patients with IGE using diffusional kurtosis imaging (DKI). MATERIALS AND
methodsWe obtained DKI and volumetric T1-weighted images from 14 patients with IGE and 25 matched healthy controls. Using tract-based spatial statistics, we performed voxel-wise group comparisons in the parametric maps generated from DKI: mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK), and in probabilistic maps of WM volume generated by voxel-based morphometry.
resultsWe observed that conventional microstructural measures (MD and FA) revealed WM abnormalities in thalamo-cortical projections, whereas MK disclosed a broader pattern of WM abnormalities involving thalamo-cortical and cortical-cortical projections.
conclusionsEven though IGE is traditionally considered a 'non-lesional' form of epilepsy, our results demonstrated pervasive thalamo-cortical WM microstructural abnormalities. Particularly, WM abnormalities shown by MK further extended into cortical-cortical projections. This suggests that the extent of microstructural abnormalities in thalamo-cortical projections in IGE may be better assessed through the diffusion metrics provided by DKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.