ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Beyond individual differences: are working memory and inhibition informative specifiers within ASD?
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-analysis of Empirical Evidence for the Simple Bayesian Model of Autism.Neuropsychology review · 2026Pooled it
- Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- The effect of computer-based cognitive flexibility training on recovery of executive function after stroke: rationale, design and methods of the TAPASS study.BMC neurology · 2015Trial
- Does Ongoing Task Load Influence Prospective Remembering in Autism Spectrum Disorders?Autism research : official journal of the International Society for Autism Research · 2026Article
- Visual body part representation of the lateral occipitotemporal cortex in individuals with autism spectrum disorder: A univariate and multivariate fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Effects of working memory load on frontal connectivity in children with autism spectrum disorder: a fNIRS study.Scientific reports · 2022Article
- Children's Pronoun Interpretation Problems Are Related to Theory of Mind and Inhibition, But Not Working Memory.Frontiers in psychology · 2021Article
- The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models.Neuroscience and biobehavioral reviews · 2018Review
- Load matters: neural correlates of verbal working memory in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2018Article
- Formal Thought Disorder and Executive Functioning in Children and Adolescents with Autism Spectrum Disorder: Old Leads and New Avenues.Journal of autism and developmental disorders · 2017Article
- Cognitive Flexibility Training: A Large-Scale Multimodal Adaptive Active-Control Intervention Study in Healthy Older Adults.Frontiers in human neuroscience · 2017Article
- Desynchronization of fronto-temporal networks during working memory processing in autism.Human brain mapping · 2016Article
- Influence of Autism Traits and Executive Functioning on Quality of Life in Children with an Autism Spectrum Disorder.Journal of autism and developmental disorders · 2015Article
- Atypical spatiotemporal signatures of working memory brain processes in autism.Translational psychiatry · 2015Article
- Binding in working memory and frontal lobe in normal aging: is there any similarity with autism?Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Findings on working memory (WM) and inhibition in children with autism spectrum disorders (ASD) are contradictory and earlier studies largely ignored individual differences. As WM and inhibition seem to be related, children who experience WM deficits might also experience inhibition deficits. Moreover, these children possibly form a distinct subgroup, differing on other variables, such as cognitive functioning, symptom severity, behavior, and attention deficit hyperactivity disorder (ADHD) characteristics. We studied a large sample of children with and without ASD (8-12 years, IQ > 80) with classic experimental tasks (n-back task, ASD n = 77, control n = 45; stop task, ASD n = 74, control n = 43), and explored individual differences. The ASD group made more errors on the n-back task with increasing WM load, and had longer stop signal reaction times on the stop task when compared with controls. However, only 6 % of the ASD group showed both WM and inhibition deficits, and 71 % showed no deficits. Parents of children with WM and/or inhibition deficits tended to report more conduct problems on the disruptive behavior disorder rating scale. ADHD characteristics did not influence performance. Some children used medication during testing, which seemingly influenced stop task performance, but excluding these data did not change the main findings. Large individual differences in cognitive functioning are present, even within children with ASD with average or above average intelligence. However, whether individual differences in specific cognitive domains, such as WM and inhibition are as informative as individual differences in diagnosis, comorbidity, and general cognitive functioning, calls for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.