ArticleObesity (Silver Spring, Md.)2014
Recruitment of fat cell precursors during high fat diet in C57BL/6J mice is fat depot specific.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Combined Exposure to Endocrine Disruptors, BPA and BP-3, during Pregnancy and Lactation Alters Postnatal Body Mass, Growth, White Adipose Tissue Morphology, and Adipogenic Gene Expression in a Sex-Specific Manner.Environment & health (Washington, D.C.) · 2026Article
- Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment.Frontiers in oncology · 2024Review
- Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice.Frontiers in endocrinology · 2022Review
- Interleukin-6 mediated exercise-induced alleviation of adiposity and hepatic steatosis in mice.BMJ open diabetes research & care · 2021Article
- Anti-Obesity and Anti-Adipogenic Effects of Chitosan Oligosaccharide (GO2KA1) in SD Rats and in 3T3-L1 Preadipocytes Models.Molecules (Basel, Switzerland) · 2021Article
- Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease.Nature metabolism · 2020Article
- Age, Diet and Epidermal Signaling Modulate Dermal Fibroblasts' Adipogenic Potential.International journal of molecular sciences · 2020Article
- Mechanisms of insulin resistance related to white, beige, and brown adipocytes.Molecular metabolism · 2020Review
- Adrenoceptors in white, brown, and brite adipocytes.British journal of pharmacology · 2019Review
- Bone Marrow Adipocyte Developmental Origin and Biology.Current osteoporosis reports · 2018Review
- Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy.Journal of animal science and biotechnology · 2017Article
- Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms.British journal of pharmacology · 2016Article
- Serially Transplanted Nonpericytic CD146(-) Adipose Stromal/Stem Cells in Silk Bioscaffolds Regenerate Adipose Tissue In Vivo.Stem cells (Dayton, Ohio) · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe study aims to explore long-term dietary effects on increases in body mass and fat depot enlargement through the recruitment of early in life labeled progenitor cells to the adipolineage.
methodsNeonate male C57BL/6J (B6) mice were injected intraperitoneally with BrdU. From 4 until 30 weeks of age they were fed either low fat diet (LFD) or high fat diet (HFD). BrdU-labeled cells were analyzed by flow cytometric and immunohistochemical assays after 10 days and 4, 8, 16, and 30 weeks.
resultsMice fed HFD were heavier than mice fed LFD with the most dramatic disparity recorded between week 16 and 30. BrdU-bearing cells showed the decrease in the percentage content of labeled cells in inguinal (iWAT), epididymal (eWAT) and bone marrow (BM) tissues, regardless diets. However, iWAT collected from animals on HFD showed significant increase in labeled-cells at week 16th, which coincides with robust increase in inguinal but not epididymal fat weight between 16 and 30 weeks age.
conclusionsCells labeled with BrdU during neonate life of B6 mice persist in fat tissues for long period of time and are recruited to the adipocyte lineage in a favorable (obesogenic) environment in iWAT but not in eWAT.
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