ReviewFrontiers in genetics2014
Pharmacogenomics and adverse drug reactions in children.
Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The effect of audio therapy to treat postoperative pain in children undergoing major surgery: a randomized controlled trial.Pediatric surgery international · 2015Trial
- Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children.British journal of clinical pharmacology · 2026Review
- Risk Factors Associated With Drug-Related Side Effects in Children: A Scoping Review.Global pediatric health · 2024Article
- Tutorial: Using Community Engagement Studios to Enhance Pharmacogenetic Study Design for Maximizing Enrollment of Diverse Children and Pregnant People.Clinical pharmacology and therapeutics · 2023Article
- No population left behind: Improving paediatric drug safety using informatics and systems biology.British journal of clinical pharmacology · 2022Review
- Pharmacogenomic markers of glucocorticoid response in congenital adrenal hyperplasia.PloS one · 2022Article
- Pharmacogenomics for Drug Dosing in Children: Current Use, Knowledge, and Gaps.Journal of clinical pharmacology · 2021Article
- Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients.JAMA network open · 2020Article
- Increased risk of hospitalization for ultrarapid metabolizers of cytochrome P450 2D6.Pharmacogenomics and personalized medicine · 2017Article
- Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.Pediatrics · 2016Article
- Review
- Use of pharmacogenomics in pediatric renal transplant recipients.Frontiers in genetics · 2015Review
- Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.American journal of human genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse drug reactions are a common and important complication of drug therapy in children. Over the past decade it has become increasingly apparent that genetically controlled variations in drug disposition and response are important determinants of adverse events for many important adverse events associated with drug therapy in children. While this research has been difficult to conduct over the past decade technical and ethical evolution has greatly facilitated the ability of investigators to conduct pharmacogenomic studies in children. Some of this research has already resulted in changes in public policy and clinical practice, for example in the case of codeine use by mothers and children. It is likely that the use of pharmacogenomics to enhance drug safety will first be realized among selected groups of children with high rates of drug use such as children with cancer, but it also likely that this research will be extended to other groups of children who have high rates of drug utilization and as well as providing insights into the mechanisms and pathophysiology of adverse drug reactions in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.