ArticleFrontiers in computational neuroscience2014
Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks.
Article in Frontiers in computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Context-Dependent modulation of astrocytic CaJournal of computational neuroscience · 2026Article
- Glial syncytial control fields and the low-frequency resonome of the human brain.Frontiers in human neuroscience · 2026Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- Parameter Inference for an Astrocyte Model using Machine Learning Approaches.bioRxiv : the preprint server for biology · 2023Article
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Article
- Reinforcing Interdisciplinary Collaborations to Unravel the Astrocyte "Calcium Code".Journal of molecular neuroscience : MN · 2022Review
- Neuron-Glia Interactions and Brain Circuits.Advances in experimental medicine and biology · 2022Article
- From nociception to pain perception, possible implications of astrocytes.Frontiers in cellular neuroscience · 2022Article
- Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout.Nanotheranostics · 2021Review
- Modeling of Astrocyte Networks: Toward Realistic Topology and Dynamics.Frontiers in cellular neuroscience · 2021Article
- Network science characteristics of brain-derived neuronal cultures deciphered from quantitative phase imaging data.Scientific reports · 2020Article
- A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate.Frontiers in computational neuroscience · 2019Article
- Generating Brain Waves, the Power of Astrocytes.Frontiers in neuroscience · 2019Review
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels.Scientific reports · 2017Article
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Glutamate mediated astrocytic filtering of neuronal activity.PLoS computational biology · 2014Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Traditionally, astrocytes have been considered to couple via gap-junctions into a syncytium with only rudimentary spatial organization. However, this view is challenged by growing experimental evidence that astrocytes organize as a proper gap-junction mediated network with more complex region-dependent properties. On the other hand, the propagation range of intercellular calcium waves (ICW) within astrocyte populations is as well highly variable, depending on the brain region considered. This suggests that the variability of the topology of gap-junction couplings could play a role in the variability of the ICW propagation range. Since this hypothesis is very difficult to investigate with current experimental approaches, we explore it here using a biophysically realistic model of three-dimensional astrocyte networks in which we varied the topology of the astrocyte network, while keeping intracellular properties and spatial cell distribution and density constant. Computer simulations of the model suggest that changing the topology of the network is indeed sufficient to reproduce the distinct ranges of ICW propagation reported experimentally. Unexpectedly, our simulations also predict that sparse connectivity and restriction of gap-junction couplings to short distances should favor propagation while long-distance or dense connectivity should impair it. Altogether, our results provide support to recent experimental findings that point toward a significant functional role of the organization of gap-junction couplings into proper astroglial networks. Dynamic control of this topology by neurons and signaling molecules could thus constitute a new type of regulation of neuron-glia and glia-glia interactions.
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