ArticleFrontiers in human neuroscience2014
Altered choroid plexus gene expression in major depressive disorder.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Choroid plexus inflammation in bipolar disorder.Brain, behavior, and immunity · 2026Article
- Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus.Fluids and barriers of the CNS · 2026Article
- Glymphatic System Dysfunction in Thyroid-Associated Ophthalmopathy: A Multimodal MRI Study.CNS neuroscience & therapeutics · 2025Article
- Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Lateral Ventricular Enlargement and Asymmetry and Myelin Content Imbalance in Individuals With Bipolar and Depressive Disorders: Clinical and Research Implications.Bipolar disorders · 2025Article
- A volumetric study of the choroid plexus in neuropsychiatric systemic lupus erythematosus.Scientific reports · 2025Article
- IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions.Journal of personalized medicine · 2024Review
- Brain ventricle and choroid plexus morphology as predictor of treatment response in major depression: Findings from the EMBARC study.Brain, behavior, & immunity - health · 2024Article
- A preliminary choroid plexus volumetric study in individuals with psychosis.Human brain mapping · 2023Article
- Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.International journal of molecular sciences · 2023Article
- Regulation of choroid plexus development and its functions.Cellular and molecular life sciences : CMLS · 2022Review
- Cobalt Neurotoxicity: Transcriptional Effect of Elevated Cobalt Blood Levels in the Rodent Brain.Toxics · 2022Article
- Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression.NeuroImage. Clinical · 2022Article
- Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression.Journal of neuroinflammation · 2021Article
- Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse.Molecular psychiatry · 2021Article
- (Biological psychiatry global open science · 2021Article
- Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis.Acta neuropathologica communications · 2020Article
- Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β.International journal of molecular medicine · 2019Article
- Connective Tissue Growth Factor Is a Novel Prodepressant.Biological psychiatry · 2018Article
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Authors and funding
8 authors.
Funding
Abstract
Given the emergent interest in biomarkers for mood disorders, we assessed gene expression in the choroid plexus (CP), the region that produces cerebrospinal fluid (CSF), in individuals with major depressive disorder (MDD). Genes that are expressed in the CP can be secreted into the CSF and may be potential biomarker candidates. Given that we have previously shown that fibroblast growth factor family members are differentially expressed in post-mortem brain of subjects with MDD and the CP is a known source of growth factors in the brain, we posed the question whether growth factor dysregulation would be found in the CP of subjects with MDD. We performed laser capture microscopy of the CP at the level of the hippocampus in subjects with MDD and psychiatrically normal controls. We then extracted, amplified, labeled, and hybridized the cRNA to Illumina BeadChips to assess gene expression. In controls, the most highly abundant known transcript was transthyretin. Moreover, half of the 14 most highly expressed transcripts in controls encode ribosomal proteins. Using BeadStudio software, we identified 169 transcripts differentially expressed (p < 0.05) between control and MDD samples. Using pathway analysis we noted that the top network altered in subjects with MDD included multiple members of the transforming growth factor-beta (TGFβ) pathway. Quantitative real-time PCR (qRT-PCR) confirmed downregulation of several transcripts that interact with the extracellular matrix in subjects with MDD. These results suggest that there may be an altered cytoskeleton in the CP in MDD subjects that may lead to a disrupted blood-CSF-brain barrier.
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