ArticleFrontiers in behavioral neuroscience2014
Complex neural codes in rat prelimbic cortex are stable across days on a spatial decision task.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Top-down corticostriatal control of adaptive restraint during motivational conflict.Science advances · 2026Article
- Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- A persistent prefrontal reference frame across time and task rules.Nature communications · 2024Article
- Optogenetic disruption of the prelimbic cortex alters long-term decision strategy but not valuation on a spatial delay discounting task.Neurobiology of learning and memory · 2023Article
- Differential processing of decision information in subregions of rodent medial prefrontal cortex.eLife · 2023Article
- Spatial Representations in Rat Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Formalizing planning and information search in naturalistic decision-making.Nature neuroscience · 2021Review
- Article
- Coordinated Prefrontal State Transition Leads Extinction of Reward-Seeking Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Early Adolescence Prefrontal Cortex Alterations in Female Rats Lacking Dopamine Transporter.Biomedicines · 2021Article
- LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields.Nature communications · 2021Article
- Central Thalamic-Medial Prefrontal Control of Adaptive Responding in the Rat: Many Players in the Chamber.Frontiers in behavioral neuroscience · 2021Article
- Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems.International review of neurobiology · 2021Review
- Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.Hippocampus · 2020Article
- Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session.Neurobiology of learning and memory · 2020Article
- Insensitivity of Place Cells to the Value of Spatial Goals in a Two-Choice Flexible Navigation Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays.Neuron · 2019Article
- Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Specific hippocampal representations are linked to generalized cortical representations in memory.Nature communications · 2018Article
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Abstract
The rodent prelimbic cortex has been shown to play an important role in cognitive processing, and has been implicated in encoding many different parameters relevant to solving decision-making tasks. However, it is not known how the prelimbic cortex represents all these disparate variables, and if they are simultaneously represented when the task requires it. In order to investigate this question, we trained rats to run the Multiple-T Left Right Alternate (MT-LRA) task and recorded multi-unit ensembles from their prelimbic regions. Significant populations of cells in the prelimbic cortex represented the strategy controlling reward receipt on a given lap, whether the animal chose to go right or left on a given lap, and whether the animal made a correct decision or an error on a given lap. These populations overlapped in the cells recorded, with several cells demonstrating differential firing to all three variables. The spatial and strategic firing patterns of individual prelimbic cells were highly conserved across several days of running this task, indicating that each cell encoded the same information across days.
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