ArticleFrontiers in neuroscience2014
Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.
Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon.Cell calcium · 2025Article
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon.Cell calcium · 2025Article
- Digestive problems in rabbit production: moving in the wrong direction?Frontiers in veterinary science · 2024Article
- Why so Many Patients With Dysphagia Have Normal Esophageal Function Testing.Gastro hep advances · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- Regional Differences in Intestinal Contractile Responses to Radial Stretch in the Human Lower Gastrointestinal Tract.Journal of neurogastroenterology and motility · 2023Article
- Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Gut feelings: mechanosensing in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System.Advances in experimental medicine and biology · 2022Review
- Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons.Frontiers in cellular neuroscience · 2022Article
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.Communications biology · 2021Article
- A myogenic motor pattern in mice lacking myenteric interstitial cells of Cajal explained by a second coupled oscillator network.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice.Gastroenterology · 2019Article
- Embryogenesis of the peristaltic reflex.The Journal of physiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propulsive contractions of circular muscle are largely responsible for the movements of content along the digestive tract. Mechanical and electrophysiological recordings of isolated colonic circular muscle have demonstrated that localized distension activates ascending and descending interneuronal pathways, evoking contraction orally and relaxation anally. These polarized enteric reflex pathways can theoretically be sequentially activated by the mechanical stimulation of the advancing contents. Here, we test the hypothesis that initiation and propagation of peristaltic contractions involves a neuromechanical loop; that is an initial gut distension activates local and oral reflex contraction and anal reflex relaxation, the subsequent movement of content then acts as new mechanical stimulus triggering sequentially reflex contractions/relaxations at each point of the gut resulting in a propulsive peristaltic contraction. In fluid filled isolated rabbit distal colon, we combined spatiotemporal mapping of gut diameter and intraluminal pressure with a new analytical method, allowing us to identify when and where active (neurally-driven) contraction or relaxation occurs. Our data indicate that gut dilation is associated with propagating peristaltic contractions, and that the associated level of dilation is greater than that preceding non-propagating contractions (2.7 ± 1.4 mm vs. 1.6 ± 1.2 mm; P < 0.0001). These propagating contractions lead to the formation of boluses that are propelled by oral active neurally driven contractions. The propelled boluses also activate neurally driven anal relaxations, in a diameter dependent manner. These data support the hypothesis that neural peristalsis is the consequence of the activation of a functional loop involving mechanical dilation which activates polarized enteric circuits. These produce propulsion of the bolus which activates further anally, polarized enteric circuits by distension, thus closing the neuromechanical loop.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.