ArticleFrontiers in neuroscience2014
Preparing for adulthood: thousands upon thousands of new cells are born in the hippocampus during puberty, and most survive with effortful learning.
Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice.Neurobiology of stress · 2026Article
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.Appetite · 2024Article
- Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.bioRxiv : the preprint server for biology · 2023Article
- Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence.Environment international · 2023Article
- Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation.Journal of neuroinflammation · 2022Article
- Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice.Environmental toxicology · 2022Article
- Association of Timing of School Desegregation in the United States With Late-Life Cognition in the Study of Healthy Aging in African Americans (STAR) Cohort.JAMA network open · 2021Article
- Adolescent Binge-Type Ethanol Exposure in Rats Mirrors Age-Related Cognitive Decline by Suppressing Cholinergic Tone and Hippocampal Neurogenesis.Frontiers in behavioral neuroscience · 2021Article
- Investigation of GluA1 and GluA2 AMPA receptor subtype distribution in the hippocampus and anterior cingulate cortex of Long Evans rats during development.IBRO reports · 2020Article
- Born this way: Hippocampal neurogenesis across the lifespan.Aging cell · 2019Review
- microRNA Expression Profiles in the Ventral Hippocampus during Pubertal Development and the Impact of Peri-Pubertal Binge Alcohol Exposure.Non-coding RNA · 2019Article
- Hippocampal subfields alterations in adolescents with post-traumatic stress disorder.Human brain mapping · 2019Article
- Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus.Neural plasticity · 2019Article
- Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.International review of neurobiology · 2019Review
- Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin.Frontiers in neuroscience · 2018Article
- Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators.Translational psychiatry · 2017Review
- Prepubertal Ovariectomy Exaggerates Adult Affective Behaviors and Alters the Hippocampal Transcriptome in a Genetic Rat Model of Depression.Frontiers in endocrinology · 2017Article
- Sexual Conspecific Aggressive Response (SCAR): A Model of Sexual Trauma that Disrupts Maternal Learning and Plasticity in the Female Brain.Scientific reports · 2016Article
- Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus.Neural plasticity · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dentate gyrus of the hippocampal formation generates new granule neurons throughout life. The number of neurons produced each day is inversely related to age, with thousands more produced during puberty than during adulthood, and many fewer produced during senescence. In adulthood, approximately half of these cells undergo apoptosis shortly after they are generated. Most of these cells can be rescued from death by effortful and successful learning experiences (Gould et al., 1999; Waddell and Shors, 2008; Curlik and Shors, 2011). Once rescued, the newly-generated cells differentiate into neurons, and remain in the hippocampus for at least several months (Leuner et al., 2004). Here, we report that many new hippocampal cells also undergo cell death during puberty. Because the juvenile brain is more plastic than during adulthood, and because many experiences are new, we hypothesized that a great number of cells would be rescued by learning during puberty. Indeed, adolescent rats that successfully acquired the trace eyeblink response retained thousands more cells than animals that were not trained, and those that failed to learn. Because the hippocampus generates thousands more cells during puberty than during adulthood, these results support the idea that the adolescent brain is especially responsive to learning. This enhanced response can have significant consequences for the functional integrity of the hippocampus. Such a massive increase in cell proliferation is likely an adaptive response as the young animal must emerge from the care of its mother to face the dangers, challenges, and opportunities of adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.