Trial reportEthiopian journal of health sciences2014
Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial.
Trial report in Ethiopian journal of health sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04009616 (Effect of Aloe Vera Mouthwashes on Plaque and Gingivitis Indices in Children), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Aloe Vera Mouthwashes on Plaque and Gingivitis Indices in Children (Clinical Randomized Controlled Trial)
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Therapeutic Potential of Latin American Medicinal Plants in Oral Diseases: From Dental Pain to Periodontal Inflammation-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis.Current pharmaceutical design · 2020Pooled it
- Effect of an Herbal Mouthwash Derived from Pedicough Syrup on Plaque, Gingival and Bleeding Indices in Patients with Gingivitis: A Randomized Controlled Trial.Journal of dentistry (Shiraz, Iran) · 2026Article
- Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.Journal of advanced periodontology & implant dentistry · 2025Article
- Article
- Aloe vera mouthwashes can be a natural alternative to chemically formulated ones - A randomized-controlled trial.Journal of Taibah University Medical Sciences · 2022Article
- Pharmacological Update Properties ofMolecules (Basel, Switzerland) · 2020Review
- Adverse events associated with home use of mouthrinses: a systematic review.Therapeutic advances in drug safety · 2019Review
- Role of Herbal Agents - Tea Tree Oil andJournal of clinical and diagnostic research : JCDR · 2017Article
- The Mouthwash War - Chlorhexidine vs. Herbal Mouth Rinses: A Meta-Analysis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Knowledge regarding prescription of drugs among dental students: A descriptive study.Journal of basic and clinical pharmacy · 2015Article
- Dental caries and their treatment needs in 3-5 year old preschool children in a rural district of India.North American journal of medical sciences · 2015Article
- Comparative Evaluation of the Complementary and Alternative Medicine Therapy and Conventional Therapy Use for Musculoskeletal Disorders Management and Its Association with Job Satisfaction among Dentists of West India.Journal of traditional and complementary medicine · 2014Article
- Acupuncture ( zhēn jiǔ) - an emerging adjunct in routine oral care.Journal of traditional and complementary medicine · 2014Review
- Assessment of Effectiveness of Barleria prionitis on Oral Health.Pharmacognosy researchArticle
- Comparative Evaluation of Triphala,Contemporary clinical dentistryArticle
- Effect of aloe vera as a preprocedural rinse in reducing aerosol contamination during ultrasonic scaling.Journal of Indian Society of PeriodontologyArticle
- Effect ofJournal of Indian Society of PeriodontologyArticle
- Prevalence of musculoskeletal disorder and alternative medicine therapies among dentists of North India: A descriptive study.Pharmacognosy researchArticle
- Are herbal mouthwash efficacious over chlorhexidine on the dental plaque?Pharmacognosy researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to increasing resistance to antibiotics and rising incidence of oral diseases, there is a need for alternative treatment modalities to combat oral diseases. The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it with the bench mark control chlorhexidine and placebo (saline water). MATERIAL AND
methodsA total of 300 systemically healthy subjects were randomly allocated into 3 groups: Aloe vera mouthwash group (n=100), control group (=100)-chlorhexidene group and saline water-Placebo (n=100). To begin with, Gingival index (GI) and plaque index (PI) were recorded. Then, baseline plaque scores were brought to zero by professionally cleaning the teeth with scaling and polishing. After randomization of the participants into three groups they were refrained from regular mechanical oral hygiene measures. Subjects were asked to swish with respective mouthwash (Aloe vera mouthwash, 0.2%chlorhexidine gluconate mouthwash, or normal saline) as per therapeutic dose for 4 days.
resultsThe results showed that Aloe vera mouthrinse is equally effective in reducing plaque as Chlorhexidine compared to placebo over a period of 4 days. There was a significant reduction on plaque in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). Aloe vera mouthwash showed no side effects.
conclusionThe results of the present study indicated that Aloe vera may prove an effective mouthwash due to its ability in reducing dental plaque.
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