Evidence map›Paper›PMID 24795507›Full record

ArticleMediators of inflammation2014

Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.

Ziming Yuan, Jingwen Zhao, Yigang Chen, Zhili Yang, Wenguo Cui, Qi Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Optimizing type H vessels formationBioactive materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ziming YuanDepartment of General Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Jingwen ZhaoOrthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, China ; School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, China.
Yigang ChenDepartment of General Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Zhili YangDepartment of General Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Wenguo CuiOrthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, China ; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, 215006, China.ORCID 0000-0002-6938-9582
Qi ZhengDepartment of General Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Shanghai Jiao Tong University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin injury in adult mammals brings about a series of events and inflammation in the wounded area is initiated first and provides lots of inflammatory factors, which is critical for the final scar formation. While the postinjured skin of fetus and nude mice heals scarlessly owing to the absence of inflammation or immunodeficient, we designed a feasible acid-responsive ibuprofen-loaded poly(L-lactide) (PLLA) fibrous scaffolds via doping sodium bicarbonate to prevent excessive inflammation and achieve scarless healing finally. The morphological results of in vivo experiments revealed that animals treated with acid-responsive ibuprofen-loaded PLLA fibrous scaffolds exhibited alleviative inflammation, accelerated healing process, and regulated collagen deposition via interference in the collagen distribution, the α-smooth muscle actin (α-SMA), and the basic fibroblast growth factor (bFGF) expression. The lower ratios of collagen I/collagen III and TGF-β1/TGF-β3 and higher ratio of matrix metalloproteinase-1 (MMP-1)/tissue inhibitor of metalloproteinase-1 (TIMP-1) in acid-responsive ibuprofen-loaded PLLA fibrous scaffolds group were confirmed by real-time qPCR as well. These results suggest that inhibiting the excessive inflammation will result in regular collagen distribution and appropriate ratio between the factors, which promote or suppress the scar formation, then decrease the scar area, and finally achieve the scarless healing.

Indexed as

AnimalsIbuprofenInflammationLactic AcidMalePolyestersPolymersRatsRats, Sprague-DawleySkinTissue ScaffoldsWound HealingIbuprofenLactic AcidPolyesterspoly(lactide)Polymers

Identifiers

PMID24795507
PMCPMC3984856
OpenAlexW2095472137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.